Drug Interactions between cefaclor and vadadustat
This report displays the potential drug interactions for the following 2 drugs:
- cefaclor
- vadadustat
Interactions between your drugs
cefaclor vadadustat
Applies to: cefaclor and vadadustat
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with vadadustat, an organic anion transporter 3 (OAT3) inhibitor, may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of OAT3. A drug interaction study evaluating the effect of repeat doses of vadadustat (600 mg once daily) on the pharmacokinetics of furosemide, an OAT1/OAT3 substrate, showed a 2-fold increase in furosemide systemic exposure (AUC).
MANAGEMENT: Caution is advised if vadadustat is used in combination with organic anion transporter 3 (OAT3) substrates. Monitoring for signs and symptoms of increased exposure to the OAT3 substrate should be considered whenever vadadustat is added to or withdrawn from therapy. The prescribing information for concomitant medications may be consulted to assess the benefits versus risks of coadministration, as well as any dosage adjustments that may be required during coadministration and/or following the discontinuation of an OAT3 inhibitor.
Drug and food interactions
vadadustat food
Applies to: vadadustat
Consumer information for this interaction is not currently available.
MONITOR: Smoking and alcohol consumption during therapy with vadadustat may increase the risk of gastrointestinal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, have been reported during vadadustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.
MANAGEMENT: Caution is advised if vadadustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.