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Drug Interactions between capivasertib and Procanbid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

procainamide capivasertib

Applies to: Procanbid (procainamide) and capivasertib

Consumer information for this interaction is not currently available.

ADJUST DOSE: Coadministration with capivasertib may increase the plasma concentrations and risk of toxicity of drugs that are substrates of the renal transporters organic cation transporter-2 (OCT2) and/or multidrug and toxin extrusion 1 or 2K (MATE1, MATE 2K). Transient increases in serum creatinine may be observed, potentially due to capivasertib-mediated inhibition of these renal transporters. However, based on physiologically based pharmacokinetic modeling, no clinically meaningful interaction was predicted with metformin, as systemic exposure (AUC) increased by 2% to 40%, depending on the capivasertib dosing day. Clinical data with other substrates of MATE1, MATE2K, and/or OCT2 are lacking.

MANAGEMENT: Caution is recommended with concomitant administration of capivasertib with OCT2, MATE 1, and/or MATE 2K substrates. According to the manufacturer, if coadministration is required, patients should be monitored for drug-related toxicities and dosage reductions considered as needed in accordance with the product labeling of the coadministered drugs.

Drug and food/lifestyle interactions

Major

capivasertib food/lifestyle

Applies to: capivasertib

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with capivasertib as they may increase the blood levels of capivasertib. This may increase the risk of side effects such as high blood sugar levels, diarrhea, skin reactions, nausea, vomiting, tiredness, and changes in certain blood tests. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

procainamide food/lifestyle

Applies to: Procanbid (procainamide)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer