Skip to main content

Drug Interactions between capivasertib and Lo Loestrin Fe

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

ethinyl estradiol capivasertib

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone) and capivasertib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with capivasertib may increase the plasma concentrations of drugs that are substrates of CYP450 3A4 via inhibition of the isoenzyme. Based on clinical studies and model-informed approaches, concomitant use of capivasertib and midazolam, a sensitive CYP450 3A4 substrate, increased midazolam systemic exposure (AUC) by 1.8-fold on day 4 and by 1.2-fold on day 7 of capivasertib treatment.

MANAGEMENT: Caution is advised if capivasertib is coadministered with CYP450 3A4 substrates, particularly sensitive substrates, or those with a narrow therapeutic range. Some authorities recommend avoiding their concomitant use; however, if coadministration cannot be avoided, they advise to adjust the dosage of the CYP450 3A4 substrate in accordance with that drug's approved product labeling. Clinical and laboratory monitoring may be appropriate whenever capivasertib is added to or withdrawn from therapy.

Drug and food/lifestyle interactions

Major

capivasertib food/lifestyle

Applies to: capivasertib

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with capivasertib as they may increase the blood levels of capivasertib. This may increase the risk of side effects such as high blood sugar levels, diarrhea, skin reactions, nausea, vomiting, tiredness, and changes in certain blood tests. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

norethindrone food/lifestyle

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone)

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Moderate

ethinyl estradiol food/lifestyle

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.

MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.

Minor

ethinyl estradiol food/lifestyle

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food/lifestyle

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Minor

norethindrone food/lifestyle

Applies to: Lo Loestrin Fe (ethinyl estradiol / norethindrone)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer