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Drug Interactions between cannabidiol and estradiol / norethindrone / relugolix

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

cannabidiol relugolix

Applies to: cannabidiol and estradiol / norethindrone / relugolix

Cannabidiol may significantly increase the blood levels of relugolix. This may increase the risk and/or severity of side effects such as hot flushes; weight gain; decreased sex drive; erectile function difficulties; muscle and joint pain; constipation; diarrhea; increases in glucose, triglyceride (fat), and liver enzyme levels; and decreased hemoglobin levels. It may also increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. If you do have to take both medications, you should take relugolix first, then take cannabidiol after at least 6 hours to minimize the effects of the interaction. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

norethindrone food

Applies to: estradiol / norethindrone / relugolix

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Moderate

cannabidiol food

Applies to: cannabidiol

Food may affect the absorption and blood levels of cannabidiol. To avoid significant fluctuations in blood levels of the medication, cannabidiol should be taken about the same time each day consistently either with or without food. Consumption of grapefruit and grapefruit juice should be limited, as it may increase the blood levels of cannabidiol. Patients who consume grapefruit or grapefruit juice may require a lower dosage of the medication based on blood levels. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

estradiol food

Applies to: estradiol / norethindrone / relugolix

Information for this minor interaction is available on the professional version.

Minor

norethindrone food

Applies to: estradiol / norethindrone / relugolix

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer