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Drug Interactions between Caltrate 600 with Iron and Vitamin D and sofosbuvir / velpatasvir / voxilaprevir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

calcium carbonate ferrous fumarate

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d) and Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

By reducing the acidity level in the stomach, medications like calcium carbonate may interfere with the absorption of ferrous fumarate into the bloodstream and reduce its effectiveness. If you require treatment with both medications, it is recommended that you take ferrous fumarate at least 2 hours before or 2 hours after calcium carbonate to help minimize the impact of the interaction. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

calcium carbonate velpatasvir

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d) and sofosbuvir / velpatasvir / voxilaprevir

Antacids may interfere with the absorption of velpatasvir and reduce its effectiveness. Products with antacid effects typically contain aluminum hydroxide, calcium carbonate, magnesium hydroxide, magnesium carbonate, magnesium oxide, magaldrate, sodium bicarbonate, and/or sodium citrate. To prevent or minimize the interaction, antacid-containing preparations should be taken 4 hours before or 4 hours after the velpatasvir dose. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

velpatasvir voxilaprevir

Applies to: sofosbuvir / velpatasvir / voxilaprevir and sofosbuvir / velpatasvir / voxilaprevir

Velpatasvir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

calcium carbonate food

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ferrous fumarate food

Applies to: Caltrate 600 with Iron and Vitamin D (calcium / ferrous fumarate / vitamin d)

Food may reduce the absorption and blood levels of ferrous fumarate. In addition, some oral medications can also interfere with ferrous fumarate absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, ferrous fumarate may interfere with the absorption of other orally administered medications. You should take ferrous fumarate on an empty stomach at least one hour before or two hours after a meal. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

voxilaprevir food

Applies to: sofosbuvir / velpatasvir / voxilaprevir

Food may help the absorption of voxilaprevir. You should take this medication with food as directed.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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