Drug Interactions between calaspargase pegol and moxifloxacin / triamcinolone

Moxifloxacin and other medications in its class can cause tendinitis and tendon rupture, and the risk may be increased when combined with a steroid such as triamcinolone. Older adults over 60 years of age and those who have received a kidney, heart, and/or lung transplant may be particularly susceptible. Tendon rupture can occur during or up to several months after finishing moxifloxacin treatment and may require surgery or result in prolonged disability. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Stop taking moxifloxacin and call your doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. You should also avoid exercise or use of the affected area until further instruction from your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using triamcinolone together with calaspargase pegol may increase your blood sugar levels. Also, this combination may increase your risks of bone-tissue death (osteonecrosis), bleeding or blood clots. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if you have symptoms of high blood sugar such as increased thirst, increased hunger, and increased urination. Also, contact your doctor if you experience bone pain or any unusual bleeding or bruising; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds. Also be alert to potential signs and symptoms of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity, and seek immediate medical attention if they occur. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Talk to your doctor before using moxifloxacin together with calaspargase pegol. Combining these medications may increase the risk of side effects such as liver damage. You may need more frequent monitoring by your doctor to safely use both medications. Let your doctor know immediately if you develop right upper quadrant pain, increasing abdominal size, fever, swelling, rash, itching, loss of appetite, fatigue, nausea, vomiting, dark urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.