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Drug Interactions between burosumab and Calphosan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

calcium glycerophosphate burosumab

Applies to: Calphosan (calcium glycerophosphate / calcium lactate) and burosumab

Using burosumab together with calcium glycerophosphate is not recommended. Combining these medications may cause excessive elevations in phosphorus and vitamin D levels in the blood, which may lead to increased risk of kidney stones. Over time, you may also have bone and muscle problems as well as increased risk of heart attacks and strokes if the blood levels remain high. Most products containing phosphates and greater than nutritional allowances of vitamin D should generally be discontinued for one week before starting treatment with burosumab. Talk to your doctor if you have any questions or concerns. During treatment, phosphorus blood levels should be closely monitored, which will allow your doctor to determine when a dose adjustment or an interruption in treatment may be required. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

calcium lactate food

Applies to: Calphosan (calcium glycerophosphate / calcium lactate)

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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