Drug Interactions between bupivacaine / lidocaine / triamcinolone and tubocurarine

Additional use of local anesthetics including lidocaine should generally be avoided within 96 hours following administration of BUPivacaine. Because the toxic effects of these medications are additive, using them together requires caution and constant monitoring of vital signs and state of consciousness to prevent serious and potentially life-threatening side effects such as methemoglobinemia (a condition that can deprive tissues and organs of oxygen), central nervous system reactions (e.G., convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.G., low blood pressure, heart block, irregular heart rhythm, cardiac arrest). Patients require immediate medical attention if they develop signs and symptoms of methemoglobinemia such as pale, gray, or blue colored skin (cyanosis); headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using tubocurarine together with lidocaine can prolong the effects of tubocurarine. You should be closely monitored for prolonged breathing cessation and respiratory paralysis after use of lidocaine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using tubocurarine together with BUPivacaine can prolong the effects of tubocurarine. You should be closely monitored for prolonged breathing cessation and respiratory paralysis after use of BUPivacaine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Triamcinolone may alter the effects of tubocurarine. In addition, there may be an increased risk of developing muscle disorders if these agents are used together for prolonged periods. Close monitoring is required. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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