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Drug Interactions between boceprevir and Danziten

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

nilotinib boceprevir

Applies to: Danziten (nilotinib) and boceprevir

Talk to your doctor before using nilotinib together with boceprevir. Combining these medications may significantly increase the blood levels of nilotinib. This can make you more likely to develop side effects such as anemia, bleeding problems, infections, or an irregular heart rhythm that may be serious or life-threatening. You may not be able to take nilotinib during treatment with boceprevir, or you may need a dose adjustment and/or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience potential signs and symptoms of these conditions such as paleness, fatigue, dizziness, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms. You should also seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with nilotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

nilotinib food

Applies to: Danziten (nilotinib)

Do not consume grapefruit or grapefruit juice during treatment with nilotinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of nilotinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with nilotinib. Food may also increase the blood levels of nilotinib. Therefore, you should take nilotinib on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking nilotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

boceprevir food

Applies to: boceprevir

Food significantly increases the absorption of boceprevir. You should take each dose of boceprevir with a meal or light snack. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer