Can you take Bleo 15k with Strontium-89 chloride?
1 drug interaction and 3 additional warnings found for the following 2 drugs:
- Bleo 15k (bleomycin)
- strontium-89 chloride
Drug interactions
Major drug interactions
Major:
bleomycin strontium-89 chloride
Applies to: Bleo 15k (bleomycin) and strontium-89 chloride
Using strontium-89 chloride together with bleomycin may increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should seek medical attention if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
3 potential interactions Applies to: 3 conditions, including Liver Disease, Renal Dysfunction, and Pulmonary Impairment.
Liver Disease
Moderate:
Bleo 15k
The bleomycin in Bleo 15k has a moderate potential interaction with Liver Disease.
The effect of hepatic insufficiency on the pharmacokinetics of bleomycin has not been evaluated. However, hepatic toxicity, beginning as a deterioration in liver function tests, has been reported. These toxicities may occur at any time after initiation of therapy. Caution and monitoring is advised if bleomycin is used in patients with liver impairment.
Pulmonary Impairment
Major:
Bleo 15k
The bleomycin in Bleo 15k has a major potential interaction with Pulmonary Impairment.
Pulmonary pneumonitis occurs in 10% of patients during bleomycin therapy and 1% progress to pulmonary fibrosis and death. Although pulmonary toxicity is age and dose related, occurring primarily in patients over 70 years of age and in those receiving a total dose > 400 units, it has occurred in younger patients at a lower dose. Extreme caution should be exercised when administering bleomycin in patients with compromised pulmonary function. Patients should be instructed to immediately report symptoms of dyspnea, cough, or congestion. Close clinical monitoring of pulmonary function is recommended.
Renal Dysfunction
Major:
Bleo 15k
The bleomycin in Bleo 15k has a major potential interaction with Renal Dysfunction.
Bleomycin is primarily eliminated by the kidney. Approximately 60% to 70% of bleomycin is excreted in the urine as active drug. Moderate renal failure reduces elimination to < 20% of the drug. Extreme caution should be exercised when administering bleomycin in patients with existing or predisposition to significantly compromised renal function. Close clinical monitoring of renal function is recommended.
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More resources
Bleo 15k
A total of 282 drugs are known to interact with Bleo 15k.
- Bleo 15k is in the drug class antibiotics/antineoplastics.
- Bleo 15k is used to treat the following conditions:
strontium-89 chloride
A total of 220 drugs are known to interact with strontium-89 chloride.
- Strontium-89 chloride is in the drug class therapeutic radiopharmaceuticals.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.