Can you take Biotene with Tromethamine?
No drug interactions found, but 7 warnings to review for the following 2 drugs:
- Biotene (fluoride topical)
- tromethamine
Drug interactions
There were no interactions found between Biotene and tromethamine. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
7 potential interactions Applies to: 7 conditions, including Seizures, Arrhythmia, Diabetes Mellitus, Hyperkalemia, and Acidosis.
Acidosis
Major:
tromethamine
Tromethamine has a major potential interaction with Acidosis.
The use of tromethamine is contraindicated in patients with chronic respiratory acidosis. Tromethamine decreases carbon dioxide tension resulting in depressed ventilation.
Alkalosis
Moderate:
tromethamine
Tromethamine has a moderate potential interaction with Alkalosis.
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
Arrhythmia
Moderate:
tromethamine
Tromethamine has a moderate potential interaction with Arrhythmia.
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
Diabetes Mellitus
Moderate:
tromethamine
Tromethamine has a moderate potential interaction with Diabetes Mellitus.
Dose-related changes in blood glucose concentrations resulting in hypoglycemia have occurred during administration of tromethamine. Rapid infusion of tromethamine has also resulted in prolonged hypoglycemia. Therapy with tromethamine should be administered cautiously in patients with diabetes and temporary dosage modification of antihyperglycemic agents may be necessary.
Hyperkalemia
Major:
tromethamine
Tromethamine has a major potential interaction with Hyperkalemia.
The use of tromethamine is contraindicated in patients with severe renal impairment (anuria, uremia) and should be administered with caution in patients with renal dysfunction. Tromethamine may accumulate in patients with renal impairment as it is not appreciably metabolized and is primarily eliminated by the kidney. Hyperkalemia may result due to tromethamine use in patients with compromised renal function. Clinical monitoring of renal function and electrolyte levels is recommended.
Renal Dysfunction
Major:
tromethamine
Tromethamine has a major potential interaction with Renal Dysfunction.
The use of tromethamine is contraindicated in patients with severe renal impairment (anuria, uremia) and should be administered with caution in patients with renal dysfunction. Tromethamine may accumulate in patients with renal impairment as it is not appreciably metabolized and is primarily eliminated by the kidney. Hyperkalemia may result due to tromethamine use in patients with compromised renal function. Clinical monitoring of renal function and electrolyte levels is recommended.
Seizures
Moderate:
tromethamine
Tromethamine has a moderate potential interaction with Seizures.
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
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More resources
Biotene
A total of 0 drugs are known to interact with Biotene.
- Biotene is in the drug class mouth and throat products.
- Biotene is used to treat Prevention of Dental Caries.
tromethamine
A total of 39 drugs are known to interact with tromethamine.
- Tromethamine is in the following drug classes: minerals and electrolytes, miscellaneous genitourinary tract agents.
- Tromethamine is used to treat Metabolic Acidosis.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.