Drug Interactions between betamethasone / iodixanol / lidocaine and iopamidol
This report displays the potential drug interactions for the following 2 drugs:
- betamethasone/iodixanol/lidocaine
- iopamidol
Interactions between your drugs
lidocaine iopamidol
Applies to: betamethasone / iodixanol / lidocaine and iopamidol
Before you undergo any imaging procedure where iopamidol may be injected directly into the spine, let your doctor know if you are currently being treated with lidocaine. Injection of iopamidol into the spine can sometimes cause seizures, and the risk may be increased if you are also using other medications that can cause seizures such as lidocaine. You may be more susceptible if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may want to withhold lidocaine for a certain length of time before and after the procedure, or you may need to be monitored more closely during the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
betamethasone iopamidol
Applies to: betamethasone / iodixanol / lidocaine and iopamidol
The injection of steroids together with radiocontrast dyes into the spine is not recommended, as it may increase the risk of seizures, meningitis, and inflammation of the spinal membranes. They may be given together by other routes.
Drug and food interactions
lidocaine food
Applies to: betamethasone / iodixanol / lidocaine
Grapefruit juice may increase the blood levels of lidocaine, which may increase the risk of side effects such as low blood pressure, slow heart rate, irregular heart rhythm, difficulty breathing and convulsions. Cigarette smoking may reduce the blood levels of lidocaine, which may make the medication less effective. It is best to avoid smoking during lidocaine therapy. Consuming cruciferous vegetables (e.G., broccoli, brussels sprouts) may also reduce the blood levels of lidocaine. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
lidocaine food
Applies to: betamethasone / iodixanol / lidocaine
Consumer information for this interaction is not currently available.
MONITOR: Smoking cessation may lead to elevated plasma concentrations and enhanced pharmacologic effects of drugs that are substrates of CYP450 1A2 (and possibly CYP450 1A1) and/or certain drugs with a narrow therapeutic index (e.g., flecainide, pentazocine). One proposed mechanism is related to the loss of CYP450 1A2 and 1A1 induction by polycyclic aromatic hydrocarbons in tobacco smoke; when smoking cessation agents are initiated and smoking stops, the metabolism of certain drugs may decrease leading to increased plasma concentrations. The mechanism by which smoking cessation affects narrow therapeutic index drugs that are not known substrates of CYP450 1A2 or 1A1 is unknown. The clinical significance of this interaction is unknown as clinical data are lacking.
MANAGEMENT: Until more information is available, caution is advisable if smoking cessation agents are used concomitantly with drugs that are substrates of CYP450 1A2 or 1A1 and/or those with a narrow therapeutic range. Patients receiving smoking cessation agents may require periodic dose adjustments and closer clinical and laboratory monitoring of medications that are substrates of CYP450 1A2 or 1A1.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Radiocontrast agents
Therapeutic duplication
The recommended maximum number of medicines in the 'radiocontrast agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'radiocontrast agents' category:
- betamethasone/iodixanol/lidocaine
- iopamidol
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Iodinated intravascular contrast agents
Therapeutic duplication
The recommended maximum number of medicines in the 'iodinated intravascular contrast agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'iodinated intravascular contrast agents' category:
- betamethasone/iodixanol/lidocaine
- iopamidol
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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