Can you take Beta-carotene with Linerixibat?
1 drug interaction and 6 additional warnings found for the following 2 drugs:
- beta-carotene
- linerixibat
Drug interactions
Moderate drug interactions
Moderate:
beta-carotene linerixibat
Applies to: beta-carotene and linerixibat
Linerixibat may decrease the absorption of fat-soluble vitamins including beta-carotene. This can increase your risk of bleeding and/or bone fractures.
You should get regular blood tests during treatment with linerixibat to check if your vitamin level is adequate, or if beta-carotene requires a dose adjustment. You may also need closer monitoring of your bone health.
If you experience bleeding problems (such as nosebleeds, bruising, prolonged bleeding from cuts, red or brown urine, or red or black stools, etc.), a bone fracture, or if your condition changes, immediately contact your doctor.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
linerixibat Food/Lifestyle
Applies to: linerixibat
To improve the effectiveness of linerixibat, take linerixibat at least 30 minutes before food or beverages (other than water).
Linerixibat may decrease the absorption of fat-soluble vitamins such as A, D, E, and K. This can increase your risk of bleeding and/or bone fractures.
You should get regular blood tests during treatment with linerixibat to check if your levels of these vitamins are adequate and if the vitamin supplement(s) you are taking require dose adjustments. You may also need closer monitoring of your bone health.
If you experience bleeding problems (such as nosebleeds, bruising, prolonged bleeding from cuts, red or brown urine, or red or black stools, etc.), a bone fracture, or your condition changes, immediately contact your doctor.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
5 potential interactions Applies to: 4 conditions, including Liver Disease, Renal Dysfunction, Malabsorption Syndrome, and Biliary Obstruction.
Biliary Obstruction
Major:
beta-carotene
Beta-carotene has a major potential interaction with Biliary Obstruction.
Vitamin A (including beta-carotene) is fat soluble and requires bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin A. Vitamin A is metabolized by the liver and primarily excreted in bile and feces. Beta-carotene is primarily metabolized in the GI mucosa to vitamin A. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of Vitamin A.
Liver Disease
Major:
beta-carotene
Beta-carotene has a major potential interaction with Liver Disease.
Vitamin A (including beta-carotene) is fat soluble and requires bile for adequate intestinal absorption. Hepatic and/or biliary dysfunction decrease the absorption of vitamin A. Vitamin A is metabolized by the liver and primarily excreted in bile and feces. Beta-carotene is primarily metabolized in the GI mucosa to vitamin A. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of Vitamin A.
Moderate:
linerixibat
Linerixibat has a moderate potential interaction with Liver Disease.
Use of linerixibat is not recommended in patients with moderate or severe liver dysfunction (Child-Pugh B or C) with decompensated cirrhosis or prior/active decompensation events (e.g. variceal hemorrhage, ascites, hepatic encephalopathy); safety and efficacy have not been evaluated.
Malabsorption Syndrome
Moderate:
beta-carotene
Beta-carotene has a moderate potential interaction with Malabsorption Syndrome.
Absorption of vitamin A depends on the presence of bile and absorbable fat in the GI tract. Prolonged fat malabsorption (cystic fibrosis, hepatic cirrhosis, sprue) or malabsorption syndromes (celiac disease, GI resection) can decrease the absorption of Vitamin A. Water- miscible vitamin A formulations may be an appropriate alternative in malabsorption conditions for certain conditions requiring vitamin A therapy.
Renal Dysfunction
Moderate:
linerixibat
Linerixibat has a moderate potential interaction with Renal Dysfunction.
The safety and effectiveness of linerixibat have not been studied in patients with severe renal impairment (estimated GFR less than 30 mL/min/1.73 m2), including those on hemodialysis. However, no adjustment of linerixibat is recommended for patients with any level of renal dysfunction.
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More resources
beta-carotene
A total of 17 drugs are known to interact with beta-carotene.
- Beta-carotene is in the drug class vitamins.
- Beta-carotene is used to treat Vitamin A Deficiency.
linerixibat
A total of 24 drugs are known to interact with linerixibat.
- Linerixibat is in the drug class miscellaneous GI agents.
- Linerixibat is used to treat Cholestatic Pruritus in Primary Biliary Cholangitis.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.