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Drug Interactions between Benicar HCT and metformin

This report displays the potential drug interactions for the following 2 drugs:

  • Benicar HCT (hydrochlorothiazide/olmesartan)
  • metformin

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Interactions between your drugs

Moderate

hydroCHLOROthiazide metFORMIN

Applies to: Benicar HCT (hydrochlorothiazide / olmesartan) and metformin

Talk to your doctor before using hydroCHLOROthiazide together with metFORMIN. HydroCHLOROthiazide can increase blood sugar levels and interfere with diabetic control. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Due to its effects on the kidneys, hydroCHLOROthiazide can also increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis that may occasionally occur during treatment with metformin-containing products. Lactic acidosis is caused by a buildup of lactic acid in the blood, and is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, dehydration, or an excess intake of alcohol. You should seek immediate medical attention if you develop potential signs and symptoms of lactic acidosis such as fatigue, weakness, muscle pain, increasing drowsiness, abdominal pain or discomfort, fast or irregular heartbeat, difficult or rapid breathing, chills, and other unusual symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

metFORMIN food

Applies to: metformin

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge drinking or frequent consumption) should be avoided during treatment. Taking metFORMIN with alcohol may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis, which is a buildup of lactic acid in the blood that can occasionally occur during treatment with metformin-containing products. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. You should seek immediate medical attention if you develop potential signs and symptoms of lactic acidosis such as fatigue, weakness, muscle pain, increasing drowsiness, abdominal pain or discomfort, slow or irregular heartbeat, breathing difficulty, chills, and other unusual symptoms. Alcohol may also affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, you should limit your alcohol intake due to the risk of lactic acidosis with metformin. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. Talk to your doctor or pharmacist if you have any questions or concerns about metformin.

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Moderate

olmesartan food

Applies to: Benicar HCT (hydrochlorothiazide / olmesartan)

If you are taking olmesartan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. This can cause high levels of potassium in your blood. High levels of potassium can cause weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Call your doctor at once if you have any of these symptoms.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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