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Drug Interactions between bedaquiline and Vivotif

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

typhoid vaccine, live bedaquiline

Applies to: Vivotif (typhoid vaccine, live) and bedaquiline

If you are currently being treated with bedaquiline or have been treated within the last 3 days, you should talk to your doctor before taking typhoid vaccine, live. Antibiotics like bedaquiline can reduce the activity of the vaccine. To ensure adequate vaccine response, you should generally not take typhoid vaccine, live until at least 3 days after you complete your antibiotic therapy. If you have already started taking typhoid vaccine, live, it may be advisable to wait at least 3 days after the last dose of vaccine before using bedaquiline, depending on the urgency of the antibiotic treatment. You should consult with your physician on what is the best course of action for you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

bedaquiline food

Applies to: bedaquiline

Food significantly increases the absorption of bedaquiline. Therefore, you should take each dose of bedaquiline with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication in treating tuberculosis. Avoid alcohol during treatment with bedaquiline, as it may increase the risk of liver damage. You should seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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