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Drug Interactions between azathioprine and Purinethol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

azaTHIOprine mercaptopurine

Applies to: azathioprine and Purinethol (mercaptopurine)

Ask your doctor before using azaTHIOprine together with mercaptopurine. Using these medications together may cause mercaptopurine to be more effective. Call your doctor at once if you have easy bruising or bleeding, fever, chills, sore throat, flu symptoms, mouth sores, dark urine, severe stomach pain, jaundice (yellowing of the skin or eyes), or severe nausea, vomiting, or diarrhea. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

mercaptopurine food

Applies to: Purinethol (mercaptopurine)

You may experience reduced absorption of mercaptopurine in the presence of food. Take mercaptopurine on an empty stomach 1 hour before or 2 hours after a meal. This will make it easier for your body to absorb the medication.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Immunity modifying agents

Therapeutic duplication

The recommended maximum number of medicines in the 'immunity modifying agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'immunity modifying agents' category:

  • azathioprine
  • Purinethol (mercaptopurine)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer