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Drug Interactions between Avtozma and ciltacabtagene autoleucel

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tocilizumab ciltacabtagene autoleucel

Applies to: Avtozma (tocilizumab) and ciltacabtagene autoleucel

Consumer information for this interaction is not currently available.

MONITOR: Although tocilizumab is used in clinical practice for the treatment of cytokine release syndrome (CRS) following ciltacabtagene autoleucel, it may significantly increase the plasma concentrations and pharmacologic effects of ciltacabtagene autoleucel. The exact mechanism of this interaction is unknown, however, in the clinical trials it was shown that ciltacabtagene autoleucel continued to expand and persist following administration of tocilizumab. In the CARTITUDE-1 study, patients treated with tocilizumab (n=68) had an increase in peak plasma concentration (Cmax) and systemic exposure (AUC (0-28d)) of ciltacabtagene autoleucel by 81% and 72%, respectively, compared to patients (n=29) who did not receive tocilizumab. Similarly, an increase in Cmax and AUC0-28d was also observed in patients who received corticosteroids and/or anakinra for treatment of CRS compared to those who did not receive corticosteroids and/or anakinra.

MANAGEMENT: Until more data are available, clinicians should be aware of the potential increase in adverse effects of ciltacabtagene autoleucel following administration of agents used in the treatment of CRS, such as tocilizumab.

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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