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Drug Interactions between Austedo XR and tetrabenazine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

tetrabenazine deutetrabenazine

Applies to: tetrabenazine and Austedo XR (deutetrabenazine)

Using tetrabenazine together with deutetrabenazine is not recommended. These medications have similar effects and taking them together can increase the risk of serious side effects. You may start taking deutetrabenazine the day after stopping tetrabenazine at the dose prescribed by your doctor. Call your doctor if you experience depression, suicidal thoughts, anxiety, restlessness, excessive drowsiness, or symptoms of parkinsonism such as slight shaking, body stiffness, trouble moving or keeping your balance. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Moderate

tetrabenazine food/lifestyle

Applies to: tetrabenazine

Alcohol can increase the nervous system side effects of tetrabenazine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with tetrabenazine. Do not use more than the recommended dose of tetrabenazine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Vmat2 inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'VMAT2 inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'VMAT2 inhibitors' category:

  • Austedo XR (deutetrabenazine)
  • tetrabenazine

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer