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Drug Interactions between asenapine and Premphase 14/14

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

conjugated estrogens asenapine

Applies to: Premphase 14 / 14 (conjugated estrogens / medroxyprogesterone) and asenapine

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of asenapine, which is partially metabolized by the isoenzyme. According to the product labeling, administration of asenapine (5 mg single dose) in combination with the potent CYP450 1A2 inhibitor fluvoxamine (25 mg twice daily for 8 days) resulted in a 13% increase in asenapine peak plasma concentration (Cmax) and a 29% increase in systemic exposure (AUC). The full therapeutic dose of fluvoxamine would be expected to cause a greater increase in asenapine plasma concentrations.

MANAGEMENT: Caution is advised if asenapine is prescribed in combination with CYP450 1A2 inhibitors. Pharmacologic response to asenapine should be monitored more closely whenever a CYP450 1A2 inhibitor is added to or withdrawn from therapy, and the asenapine dosage adjusted as necessary.

Drug and food interactions

Moderate

asenapine food

Applies to: asenapine

Alcohol can increase the nervous system side effects of asenapine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with asenapine. Do not use more than the recommended dose of asenapine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Minor

conjugated estrogens food

Applies to: Premphase 14 / 14 (conjugated estrogens / medroxyprogesterone)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer