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Drug Interactions between asciminib and vibegron

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

vibegron asciminib

Applies to: vibegron and asciminib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with asciminib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. In vitro, asciminib is a substrate and inhibitor of P-gp, an efflux transporter expressed in the gastrointestinal tract, liver, and kidney. However, drug interaction studies with P-gp substrates have not been conducted.

MANAGEMENT: Caution is advised when asciminib is used concomitantly with drugs that are substrates of P-gp, particularly sensitive substrates or those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever asciminib is added to or withdrawn from therapy. The prescribing information recommends closely monitoring for the development of adverse reactions in patients receiving asciminib therapy with certain P-gp substrates where minimal concentration changes may lead to serious or life-threatening toxicities. In addition, the prescribing information for concomitant medications should be consulted to assess the benefits versus risks of coadministration of a P-gp inhibitor like asciminib and for any dosage adjustments that may be required.

Drug and food interactions

Moderate

asciminib food

Applies to: asciminib

Food may reduce the absorption of asciminib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should avoid eating for at least 2 hours before and 1 hour after taking asciminib. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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