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Drug Interactions between amifostine and lofexidine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amifostine lofexidine

Applies to: amifostine and lofexidine

If you are currently being treated with lofexidine, let your doctor know before you receive amifostine. Combining these medications may have additive effects in lowering your blood pressure. Depending on your condition, your doctor may want you to discontinue lofexidine for 24 hours before you receive treatment with amifostine, and your blood pressure will need to be monitored closely during and after the treatment. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Contact your doctor if you develop these symptoms and they do not go away after a few hours, or they become troublesome. You should avoid rising abruptly from a sitting or lying position until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

lofexidine food

Applies to: lofexidine

Alcohol can increase the nervous system side effects of lofexidine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with lofexidine. Do not use more than the recommended dose of lofexidine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.