Drug Interactions between alpelisib and dronabinol

Do not use alcohol while you are receiving treatment with droNABinol. This may increase nervous system side effects such as somnolence, dizziness, confusion, difficulty concentrating, and impairment in thinking and judgment. You should also avoid consuming grapefruit and grapefruit juice, as this may increase the blood levels and effects of droNABinol. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Take droNABinol exactly as your doctor tells you to. Do not exceed the dose of droNABinol prescribed for you or use the medication more frequently or for a longer duration than prescribed by your doctor. Also, avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

Food significantly enhances the absorption of alpelisib. You should take each dose of alpelisib at the same time each day with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking alpelisib with food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.