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Drug Interactions between Allegra-D 24 Hour Allergy & Congestion and niraparib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fexofenadine niraparib

Applies to: Allegra-D 24 Hour Allergy & Congestion (fexofenadine / pseudoephedrine) and niraparib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with niraparib may increase the plasma concentrations of drugs that are substrates of the multidrug and toxin extrusion (MATE) 1 and/or 2 transporters. The proposed mechanism is MATE 1 and/or 2 inhibition by niraparib. However, the clinical significance of this interaction is unclear.

MANAGEMENT: Caution is recommended if niraparib is used in combination with substrates of the multidrug and toxin extrusion (MATE) 1 and/or 2 transporters like metformin. Monitoring for signs and symptoms of increased exposure to the MATE 1 and 2 substrates should be considered whenever niraparib is added to or withdrawn from therapy.

References

  1. "Product Information. Akeega (abiraterone-niraparib)." Janssen Biotech, Inc. (2023):
  2. "Product Information. Zejula (niraparib)." GlaxoSmithKline (2023):
  3. "Product Information. Zejula (niraparib)." GlaxoSmithKline Inc (2023):
  4. "Product Information. Akeega (abiraterone-niraparib)." Janssen Inc (2023):
  5. "Product Information. Zejula (niraparib)." GlaxoSmithKline Australia Pty Ltd (2023):
  6. "Product Information. Zejula (niraparib)." GlaxoSmithKline UK Ltd (2023):
View all 6 references

Drug and food interactions

Moderate

fexofenadine food

Applies to: Allegra-D 24 Hour Allergy & Congestion (fexofenadine / pseudoephedrine)

Consuming large amounts of certain fruit juices, including grapefruit, orange and apple, may decrease the levels of fexofenadine in your body. Fexofenadine should be taken with water and refrain from drinking large amounts of grapefruit, orange, or apple juice. This will make it easier for your body to absorb the medication.

Switch to professional interaction data

Moderate

pseudoephedrine food

Applies to: Allegra-D 24 Hour Allergy & Congestion (fexofenadine / pseudoephedrine)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References

  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
  3. "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc PROD (2001):
  4. "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals PROD (2001):
  5. "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals PROD (2001):
  6. "Product Information. Focalin (dexmethylphenidate)." Mikart Inc (2001):
  7. "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company (2002):
View all 7 references

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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