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Drug Interactions between Alka-Seltzer Wake-Up Call! and momelotinib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

caffeine momelotinib

Applies to: Alka-Seltzer Wake-Up Call! (aspirin / caffeine) and momelotinib

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of momelotinib may decrease the plasma concentrations and effects of drugs that are substrates of CYP450 1A2. The proposed mechanism, based on in vitro data, is increased drug clearance due to momelotinib-mediated induction of the CYP450 1A2 isoenzyme. However, clinical data are not available.

MANAGEMENT: Caution is recommended with the concomitant use of momelotinib and CYP450 1A2 substrates, particularly those with a narrow therapeutic index. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever momelotinib is added to or withdrawn from therapy with these drugs. Individual product labeling for the coadministered drug may also be consulted for specific guidance.

Minor

aspirin caffeine

Applies to: Alka-Seltzer Wake-Up Call! (aspirin / caffeine) and Alka-Seltzer Wake-Up Call! (aspirin / caffeine)

Information for this minor interaction is available on the professional version.

Drug and food/lifestyle interactions

Moderate

aspirin food/lifestyle

Applies to: Alka-Seltzer Wake-Up Call! (aspirin / caffeine)

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

caffeine food/lifestyle

Applies to: Alka-Seltzer Wake-Up Call! (aspirin / caffeine)

Information for this minor interaction is available on the professional version.

Minor

aspirin food/lifestyle

Applies to: Alka-Seltzer Wake-Up Call! (aspirin / caffeine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer