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Drug Interactions between Alka-Seltzer Plus Cold Powerfast Fizz Night and donepezil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dextromethorphan doxylamine

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine) and Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Using dextromethorphan together with doxylamine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

doxylamine donepezil

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine) and donepezil

Talk to your doctor before using doxylamine together with donepezil. Medications like doxylamine may reduce the effectiveness of donepezil. In addition, patients with Alzheimer's disease or other dementia may be more likely to experience nervous system side effects of doxylamine such as drowsiness, confusion, and mental impairment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

aspirin donepezil

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine) and donepezil

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

dextromethorphan food

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

doxylamine food

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Alcohol can increase the nervous system side effects of doxylamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with doxylamine. Do not use more than the recommended dose of doxylamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

aspirin food

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Ask your doctor before using aspirin together with ethanol. Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenylephrine food

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Both phenylephrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

aspirin food

Applies to: Alka-Seltzer Plus Cold Powerfast Fizz Night (aspirin / dextromethorphan / doxylamine / phenylephrine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer