Drug Interactions between aliskiren / hydrochlorothiazide and venetoclax

Food helps to increase the absorption of venetoclax. You should take each dose of venetoclax with a meal and water at approximately the same time each day. Do not consume grapefruit, grapefruit juice, Seville oranges, or starfruit during treatment with venetoclax. Doing so can significantly increase blood levels and effects of the medication. This may increase your risk of developing tumor lysis syndrome, a serious condition that is caused by the rapid breakdown of cancer cells and that can lead to kidney failure and even death. In addition, you may be more likely to experience other side effects such as nausea, vomiting, diarrhea, fatigue, and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can affect the absorption of aliskiren from the intestine. Therefore, you should take aliskiren at the same time each day exactly as prescribed by your doctor. You may take aliskiren with or without food, but take it the same way every time. This will help keep blood levels and effects of the medication steady. You should avoid drinking orange, apple, or grapefruit juice as much as possible during treatment with aliskiren. Studies have shown that drinking these juices regularly or within a short period before or after a dose of aliskiren can interfere with the absorption of the medication.

HydroCHLOROthiazide and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.