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Drug Interactions between Alamag Plus and patiromer

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

aluminum hydroxide patiromer

Applies to: Alamag Plus (aluminum hydroxide / magnesium hydroxide / simethicone) and patiromer

Aluminum hydroxide may reduce the effectiveness of patiromer in binding potassium. In addition, combining these medications may increase the risk of developing metabolic alkalosis, which is a pH imbalance in the body caused by accumulation of an alkaline substance such as bicarbonate. It may be more likely to occur if you have severe kidney impairment. Symptoms of metabolic alkalosis may include nausea, vomiting, lightheadedness, tremor, muscle twitching, numbness or tingling, prolonged muscle spasms, slowed breathing, irregular heartbeat, confusion, and stupor. Severe cases may lead to seizure and coma. Do not take any over-the-counter antacids or laxatives without consulting with a healthcare professional first. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

magnesium hydroxide patiromer

Applies to: Alamag Plus (aluminum hydroxide / magnesium hydroxide / simethicone) and patiromer

Magnesium hydroxide may reduce the effectiveness of patiromer in binding potassium. In addition, combining these medications may increase the risk of developing metabolic alkalosis, which is a pH imbalance in the body caused by accumulation of an alkaline substance such as bicarbonate. It may be more likely to occur if you have severe kidney impairment. Symptoms of metabolic alkalosis may include nausea, vomiting, lightheadedness, tremor, muscle twitching, numbness or tingling, prolonged muscle spasms, slowed breathing, irregular heartbeat, confusion, and stupor. Severe cases may lead to seizure and coma. Do not take any over-the-counter antacids or laxatives without consulting with a healthcare professional first. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

aluminum hydroxide food

Applies to: Alamag Plus (aluminum hydroxide / magnesium hydroxide / simethicone)

Citrate, or citric acid, can increase the absorption of aluminum hydroxide. This may lead to elevated blood levels of aluminum, particularly in individuals with reduced kidney function, since aluminum is primarily eliminated by the kidneys. Excess aluminum may deposit and cause problems in various tissues including bone, brain, heart, liver, muscles, and spleen. Over time, weak bones, bone pain, fractures, skeletal deformity, brain disorders, and anemia may develop. Talk to your doctor before using aluminum hydroxide if you have kidney impairment or are on hemodialysis. You should avoid or limit the consumption of citrate-containing foods and beverages (e.G., soft drinks, citrus fruits, fruit juices) during treatment with aluminum hydroxide. Be aware that some effervescent and dispersible drug formulations may also contain citrate and should be restricted as well. Even if you do not have kidney problems, it may be best to separate the dosing of aluminum hydroxide and citrate-containing products by 2 to 3 hours. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

When aluminum hydroxide is taken during enteral nutrition therapy (tube feeding), the tube may get clogged. Therefore, aluminum hydroxide should not be mixed with or given after high-protein tube feedings. The dose should be separated from the feeding by as much as possible, and the tube should be thoroughly flushed before administration of the dose.

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Moderate

patiromer food

Applies to: patiromer

Patiromer may bind to many different oral medications in the gastrointestinal tract and reduce their absorption into the blood stream. The effectiveness of some oral medications may be decreased when taken with patiromer. To minimize the possibility of interaction, it is recommended that you separate the dosing times of patiromer and any oral medication you take by at least three hours. Talk to your doctor if you are unable to do so or if you have other questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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