Drug Interactions between Afinitor Disperz and entrectinib
This report displays the potential drug interactions for the following 2 drugs:
- Afinitor Disperz (everolimus)
- entrectinib
Interactions between your drugs
everolimus entrectinib
Applies to: Afinitor Disperz (everolimus) and entrectinib
Entrectinib may increase the blood levels of everolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience new or worsening side effects of everolimus such as mouth ulcers, fever, infection, shortness of breath, diarrhea, dizziness, paleness, fainting, and/or unusual bleeding or bruising while taking these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
entrectinib food
Applies to: entrectinib
Do not consume grapefruit, grapefruit juice, or Seville oranges during treatment with entrectinib. Doing so can significantly increase the blood levels of entrectinib and increase the risk and/or severity of side effects such as dizziness; confusion; hallucinations; problems with concentration, attention, thinking, and memory; mood changes; insomnia; drowsiness; liver problems; increased uric acid levels in the blood (hyperuricemia); congestive heart failure; fluid retention and swelling; changes in electrical activity of the heart (a condition known as QT prolongation, which may lead to irregular heart rhythm that can be life-threatening); vision problems; and low red or white blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
everolimus food
Applies to: Afinitor Disperz (everolimus)
Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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