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Drug Interactions between Adoxa and Estrasorb

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

doxycycline estradiol

Applies to: Adoxa (doxycycline) and Estrasorb (estradiol)

Antibiotics such as doxycycline may reduce the effects of estradiol in some women. If you are using estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. Be sure to alert your doctor if you are having any vomiting and/or diarrhea as this too can impact how well estradiol works. Talk to your doctor or pharmacist to determine if you should use an alternative or additional form of birth control during or after treatment with doxycycline. In addition, some birth control preparations may include "placebo" non-hormonal pills that contain iron. If you are taking these iron-containing pills during treatment with doxycycline, you should separate the dosing times by several hours so that the iron does not interfere with absorption of the antibiotic. Ask your doctor or pharmacist for information on when best to take these medications. If you are using estradiol for a purpose other than birth control, please let your doctor know if you have any questions or notice any changes in how well estradiol is working. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Moderate

doxycycline food/lifestyle

Applies to: Adoxa (doxycycline)

Consumer information for this interaction is not currently available.

GENERALLY AVOID: The oral bioavailability of quinolone and tetracycline antibiotics may be reduced by concurrent administration of preparations containing polyvalent cations such as aluminum, calcium, iron, magnesium, and zinc. Therapeutic failure may result. The proposed mechanism is chelation of quinolone and tetracycline antibiotics by di- and trivalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. Reduced gastrointestinal absorption of the cations should also be considered.

MANAGEMENT: Concomitant administration of oral quinolone and tetracycline antibiotics with preparations containing aluminum, calcium, iron, magnesium, and/or zinc salts should generally be avoided. Otherwise, the times of administration should be staggered by as much as possible to minimize the potential for interaction. Quinolones should typically be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation preparations, depending on the quinolone and formulation. Likewise, tetracyclines and polyvalent cation preparations should typically be administered 2 to 4 hours apart. The prescribing information for the antibiotic should be consulted for more specific dosing recommendations.

Minor

estradiol food/lifestyle

Applies to: Estrasorb (estradiol)

Information for this minor interaction is available on the professional version.

Minor

doxycycline food/lifestyle

Applies to: Adoxa (doxycycline)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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