Drug Interactions between 5-hydroxytryptophan / melatonin / pyridoxine and zuranolone
This report displays the potential drug interactions for the following 2 drugs:
- 5-hydroxytryptophan/melatonin/pyridoxine
- zuranolone
Interactions between your drugs
melatonin zuranolone
Applies to: 5-hydroxytryptophan / melatonin / pyridoxine and zuranolone
Zuranolone may cause sedation, dizziness, confusion, and trouble walking. The risk and/or severity may be increased when combined with other antidepressants or other medications that can also cause sedation. Let your doctor know prior to receiving zuranolone if you are currently using alcohol or receiving treatment with melatonin, as you may be more likely to experience sedation-related side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
5-hydroxytryptophan zuranolone
Applies to: 5-hydroxytryptophan / melatonin / pyridoxine and zuranolone
Zuranolone may cause sedation, dizziness, confusion, and trouble walking. The risk and/or severity may be increased when combined with other antidepressants or other medications that can also cause sedation. Let your doctor know prior to receiving zuranolone if you are currently using alcohol or receiving treatment with 5-hydroxytryptophan, as you may be more likely to experience sedation-related side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
melatonin food
Applies to: 5-hydroxytryptophan / melatonin / pyridoxine
Both smoking and excessive caffeine consumption can alter the blood levels of melatonin, which may affect the dosing. Tobacco smoking reduces, while caffeine increases melatonin blood levels. If you start smoking or undergo smoking cessation, your doctor may need to adjust the dose of melatonin. In addition, alcohol may reduce the effect of melatonin on sleep. It is best to avoid alcohol consumption during melatonin therapy. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
zuranolone food
Applies to: zuranolone
Zuranolone must be taken with fat-containing food to ensure adequate absorption of the mediation. It is also best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of zuranolone. You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Miscellaneous antidepressants
Therapeutic duplication
The recommended maximum number of medicines in the 'miscellaneous antidepressants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'miscellaneous antidepressants' category:
- 5-hydroxytryptophan/melatonin/pyridoxine
- zuranolone
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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