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What are Ketolides?

Ketolides are a new generation of macrolide antibiotics designed to overcome issues with bacterial resistance to macrolides. They are semi-synthetic antibiotics derived from erythromycin (macrolide antibiotic) and the changes give ketolides a broader spectrum of activity.

Ketolides bind to the bacterial 50S ribosomal subunit and inhibit RNA-dependent protein synthesis. They are bacteriostatic at low concentrations and bactericidal at high concentration, so basically exhibit concentration dependent killing.

Ketolides have good antibacterial activity against Gram-positive bacteria such as those that cause respiratory tract infections.

List of Ketolides:

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Drug NameView by: Brand | Generic Reviews Avg. Ratings
Ketek (Pro, More...)
generic name: telithromycin
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Ketek Pak (More...)
generic name: telithromycin
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See Also

Medical conditions associated with ketolides: