Jynarque (tolvaptan) Disease Interactions
There are 3 disease interactions with Jynarque (tolvaptan):
Tolvaptan (applies to Jynarque) liver impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Tolvaptan can cause serious and potentially fatal liver injury. Patients with symptoms that indicate liver injury such as fatigue, anorexia, right upper abdominal pain, dark urine or jaundice should discontinue treatment right away. Therapy duration should be limited to 30 days. The use of tolvaptan should be avoided in patients with underlying liver disease, including cirrhosis, because the ability to recover from liver injury may be impaired.
Tolvaptan (applies to Jynarque) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
There are no clinical trials of tolvaptan in patients with CrCl < 10 mL/min, and because drug effects on serum sodium levels are likely lost at very low levels of renal function, use in these patients is not recommended. Additionally, no benefit can be expected in anuric patients, so the use of tolvaptan is contraindicated in these patients.
Vasopressin antagonists (applies to Jynarque) liver disease/alcoholism
Moderate Potential Hazard, Moderate plausibility.
Osmotic demyelination syndrome is a risk associated with overly rapid correction of hyponatremia (> 12 mEq/L/24 hours). This syndrome can result in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizure, coma or death. Patients with advanced liver disease, alcoholism or severe malnutrition are at increased risk and require slower rates of correction. Serum sodium concentration and neurological status should be monitored appropriately during treatment administration. Vasopressin antagonists should be initiated and re- initiated in patients only in hospital settings were sodium levels can be monitored closely.
Jynarque (tolvaptan) drug interactions
There are 269 drug interactions with Jynarque (tolvaptan)
Jynarque (tolvaptan) alcohol/food interactions
There is 1 alcohol/food interaction with Jynarque (tolvaptan)
More about Jynarque (tolvaptan)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|