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NuDiclo SoluPak Disease Interactions

There are 5 disease interactions with NuDiclo SoluPak (capsaicin / diclofenac topical).

Major

NSAIDs (applies to NuDiclo SoluPak) asthma

Major Potential Hazard, High plausibility.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated in patients with history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs; severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients. A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps, severe potentially fatal bronchospasm, and/or intolerance to aspirin and other NSAIDs. Since cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, therapy with any NSAID should be avoided in patients with this form of aspirin sensitivity. NSAIDs should be used with caution in patients with preexisting asthma (without known aspirin sensitivity), and these patients should be monitored for changes in the signs and symptoms of asthma.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Nalfon (fenoprofen)." Xspire Pharma PROD (2002):
  3. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  4. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories PROD (2002):
  5. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  6. "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
  7. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical PROD (2001):
  8. "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
  9. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  10. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  11. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  12. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  13. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  14. "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
  15. "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim PROD (2001):
View all 15 references
Moderate

Diclofenac topical (applies to NuDiclo SoluPak) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

No information is available from controlled clinical trials regarding the use of topical diclofenac in patients with advanced renal disease. Therefore, treatment with this drug is not recommended in patients with advanced renal disease. If therapy with topical diclofenac is initiated, close monitoring of the patient's renal function is advisable.

References

  1. "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
Moderate

NSAIDs (applies to NuDiclo SoluPak) heart failure

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure

Fluid retention and edema have been observed in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs), including some topical formulations. These drugs should be avoided in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure. If an NSAID is used in patients with severe heart failure, they should be monitored for signs of worsening heart failure.

References

  1. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  2. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  3. "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
  4. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  5. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  6. "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
  7. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  8. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  9. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  10. "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
  11. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc (2012):
  12. "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
View all 12 references
Moderate

NSAIDs (applies to NuDiclo SoluPak) hypertension

Moderate Potential Hazard, Moderate plausibility.

Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. NSAIDs should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

References

  1. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  2. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  3. "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
  4. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  5. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  6. "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
  7. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  8. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  9. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  10. "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
  11. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc (2012):
  12. "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
View all 12 references
Moderate

NSAIDs (applies to NuDiclo SoluPak) platelet aggregation inhibition

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect, Thrombocytopenia, Vitamin K Deficiency

Nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit platelet adhesion and aggregation and may prolong bleeding time in some patients. With the exception of aspirin, the platelet effects seen with most NSAIDs at usual recommended dosages are generally slight and of relatively short duration but may be more pronounced in patients with underlying hemostatic abnormalities. Thrombocytopenia has also been reported rarely during NSAID use. Therapy with NSAIDs should be administered cautiously in patients with significant active bleeding or a hemorrhagic diathesis, including hemostatic and/or coagulation defects associated with hemophilia, vitamin K deficiency, hypoprothrombinemia, thrombocytopenia, thrombocytopathy, or severe hepatic impairment. NSAIDs that selectively inhibit cyclooxygenase-2 (i.e., COX-2 inhibitors) do not appear to affect platelet function or bleeding time at indicated dosages and may be preferable if risk of bleeding is a concern.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Nalfon (fenoprofen)." Xspire Pharma PROD (2002):
  3. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  4. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories PROD (2002):
  5. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  6. "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
  7. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical PROD (2001):
  8. "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
  9. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  10. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  11. "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
  12. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  13. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  14. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  15. "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim PROD (2001):
  16. "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
View all 16 references

NuDiclo SoluPak drug interactions

There are 132 drug interactions with NuDiclo SoluPak (capsaicin / diclofenac topical).

NuDiclo SoluPak alcohol/food interactions

There is 1 alcohol/food interaction with NuDiclo SoluPak (capsaicin / diclofenac topical).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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