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TissueBlue (Ophthalmic)

Generic name: brilliant blue g (ophthalmic route)
Drug class: Ophthalmic diagnostic agents

Medically reviewed by Last updated on Sep 13, 2022.

Commonly used brand name(s)

In the U.S.

  • TissueBlue

Available Dosage Forms:

  • Solution

Therapeutic Class: Surgical Aid, Ocular

Uses for TissueBlue

Brilliant blue G is a surgical aid during eye surgery. It is a blue dye that works by selectively staining the internal limiting membrane of the retina. This creates a contrast between different parts of the eye and helps the doctor to see the internal limiting membrane of the retina more clearly.

This medicine is to be given only by or under the direct supervision of the doctor.

Before using TissueBlue

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of brilliant blue G in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of brilliant blue G in the elderly.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of TissueBlue

Your doctor will be put this medicine into your eye during surgery. Any extra amount of this medicine will be washed out of your eye at the end of the surgery.

Precautions while using TissueBlue

Your doctor will want to check your progress at regular visits during the first few weeks after you receive this medicine.

TissueBlue side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

  • Blindness
  • blurred vision
  • decreased vision or other changes in vision
  • seeing floaters or light flashes
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

More about TissueBlue (brilliant blue g ophthalmic)

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.