Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Blood Modifier Agent
Uses for plasma
Plasma injection is used as a replacement of multiple coagulation (clotting) factors in patients with acquired deficiencies due to liver disease, or undergoing heart surgery or liver transplant. Plasma is also used in plasma exchange in patients with thrombotic thrombocytopenic purpura (TTP).
Plasma is to be given only by or under the direct supervision of a doctor.
Before using plasma
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For plasma, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to plasma or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of plasma injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies have not been performed on the relationship of age to the effects of plasma injection in the geriatric population. Safety and efficacy have not been established.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of plasma. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to fresh frozen plasma (FFP) or plasma-derived products (eg, plasma protein), history of or
- Immunoglobulin A (IgA) deficiency or
- Protein S deficiency, severe—Should not be used in patients with these conditions.
- Bleeding problems or
- Heart failure or
- Pulmonary edema (fluid in the lungs)—Use with caution. May cause side effects to become worse.
- Liver disease—Use with caution. May increase risk for more serious side effects.
- Liver transplant—Patients with this condition should be monitored for increased bleeding.
Proper use of plasma
A nurse or other trained health professional will give you plasma in a hospital. Plasma is given through a needle placed in one of your veins.
Your doctor may want you to have blood tests before receiving plasma. Plasma is given only based on ABO-blood group compatibility.
Precautions while using plasma
Your doctor will check your progress closely while you are receiving plasma. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.
Plasma may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, lightheadedness or dizziness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using plasma.
Tell your doctor right away if you have a chest pain, difficult noisy breathing, swelling of the face, fingers, feet, or lower legs, troubled breathing, or weight gain. These could be symptoms of heart failure and pulmonary edema.
Tell your doctor right away if you have tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins at the injection site. These could be symptoms of a blood clotting problem caused by low levels of Protein S.
Using too much of plasma may cause citrate toxicity or hypocalcemia (low calcium in the blood). Tell your doctor right away if you have confusion, convulsions, muscle spasms, numbness or tingling sensation around the mouth, fingertips, or feet, or unusual tiredness or weakness.
Plasma is made from donated human blood. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor about this risk if you are concerned.
Plasma side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
Incidence not known
- Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- hives, itching, or rash
- muscle cramps in the hands, arms, feet, legs, or face
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- tightness in the chest
- unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Bleeding, blistering, discomfort, infection, itching, lumps, numbness, pain, rash, redness, stinging, swelling, tenderness, tingling, or warmth at the injection site
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.