Medically reviewed on Oct 31, 2018
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Disclosing Agent
Uses For fluorescein
Fluorescein injection is used to help certain parts of the eye (eg, retina, iris) become more visible during eye medical procedures.
Fluorescein is to be given only by or under the direct supervision of your doctor.
Before Using fluorescein
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fluorescein, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to fluorescein or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluorescein injection in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluorescein injection in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of fluorescein. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to food, dye, or medicine, history of or
- Asthma, or history of—May increase risk of having an allergic reaction to occur again.
Proper Use of fluorescein
A nurse or other trained health professional will give you or your child fluorescein in a hospital. Fluorescein is given through a needle placed in one of your veins.
Precautions While Using fluorescein
Your doctor will check your progress closely while you or your child is receiving fluorescein. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it and to check for unwanted effects.
Fluorescein may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, or fainting. Other signs may include changes in color of the skin of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and puffiness or swellings of the eyelids or around the eyes. If these side effects occur, get emergency help at once.
Tell your doctor right away if you or your child has redness, swelling, or peeling of the skin, or severe pain or loss of feeling in the arm for several hours after receiving fluorescein.
Tell your doctor if you or your child has nausea, vomiting, diarrhea, or stomach pain after receiving fluorescein.
You or your child may notice a strong taste in your mouth after fluorescein is injected. Your skin may have a yellowish discoloration for about 6 to 12 hours after your test. Your urine may appear bright yellow for up to 36 hours after your test.
Fluorescein Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Bluish color
- cold, clammy skin
- difficulty breathing
- difficulty swallowing
- fast heartbeat
- hives, itching, or skin rash
- noisy breathing
- pain, redness, swelling, or peeling of the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe pain in the arm
- tightness in the chest
- unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal or stomach pain
- yellow skin and urine
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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