amifostine (Intravenous route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Cytoprotective Agent
Uses For amifostine
Amifostine is used to help prevent or lessen some of the side effects on the kidneys and salivary glands that are caused by cisplatin (a cancer medicine) or radiation therapy.
Amifostine is to be given only by or under the immediate supervision of your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in the product labeling, amifostine is used in certain patients with the following medical conditions:
- Mucositis in patients receiving radiation therapy or radiation combined with chemotherapy
- Myelodysplastic syndromes
Before Using amifostine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amifostine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to amifostine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of amifostine in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amifostine in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney disease, which may require an adjustment of dose in patients receiving amifostine.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving amifostine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using amifostine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine
Using amifostine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Yellow Fever Vaccine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of amifostine. Make sure you tell your doctor if you have any other medical problems, especially:
- Congestive heart failure or
- Heart attack, history of, or
- Heart disease or
- Heart rhythm problems or
- Kidney disease or
- Stroke, history of, or
- Transient ischemic attacks (TIA or mini-stroke), history of—Use with caution. May cause side effects to become worse.
- Dehydration or
- Low blood pressure—Should not be used in patients with these conditions.
Proper Use of amifostine
A nurse or other trained health professional will give you amifostine in a hospital or cancer treatment center. amifostine is given through a needle placed in one of your veins.
amifostine is given before cisplatin therapy or radiation therapy. You may also receive other medicines to help prevent nausea and vomiting.
Drink plenty of fluids during the 24 hours before receiving amifostine.
Precautions While Using amifostine
It is very important that your doctor check your progress at regular visits to allow for changes in your dose. Blood tests may be needed to check for any unwanted effects.
Low blood pressure (hypotension) may occur with amifostine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness.
Serious skin reactions can occur with amifostine. Check with your doctor right away if you have a rash on the lips or mouth; red skin lesions on the palms of the hands or soles of the feet; sores or ulcers on the skin; or fever or chills while you are receiving amifostine.
amifostine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; trouble breathing; any swelling of your hands, face, or mouth; or chest pain after you receive amifostine.
amifostine may cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
amifostine Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- fainting or loss of consciousness
- fast or irregular breathing
- nausea and vomiting
- red, scaly, swollen, or peeling areas of the skin
- skin rash
- swelling of the eyes or eyelids
- tightness in the chest
- trouble with breathing
- unusual tiredness or weakness
- Abdominal cramps
- blistering, peeling, or loosening of the skin
- burning or tingling sensation
- cracks in the skin
- difficulty in breathing
- fast, slow, or irregular heartbeat or pulse
- joint or muscle pain
- loss of bladder control
- loss of heat from the body
- muscle cramps in the hands, arms, feet, legs, or face
- muscle spasm or jerking of all extremities
- no blood pressure or pulse
- numbness and tingling around the mouth, fingertips, or feet
- red irritated eyes
- red skin lesions, often with a purple center
- shortness of breath
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- stopping of the heart
- sudden loss of consciousness
- Difficulty in swallowing
- hives or welts
- slow or irregular breathing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common or rare
- Feeling unusually warm or cold
- flushing or redness of the face or neck
- pounding in the ears
- sleepiness (severe)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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