Other names: Autoinflammatory Disease; Autoinflammatory Syndromes
Periodic fever syndromes (or autoinflammatory disease) results from disorders of the innate immune system causing intense episodes of inflammation. The symptoms are recurrent episodes of fever, rash, joint swelling, abdominal or chest pain without an increase in autoantibodies or antigen-specific T cells. Often periodic fever syndromes have a clear genetic cause and these individual syndromes are defined by the responsible gene. Other periodic fever syndromes are non hereditary and the cause of these syndromes is still not fully understood.
