Clotic
Pronunciation: cloh-tic
Generic name: clotrimazole otic solution
Brand name: Clotic
Dosage form: ear drops (1%/0.17mL)
What is Clotic? Fungal Ear Infection Treatment
Clotic is an antifungal ear drop used to treat fungal otitis externa (otomycosis) in adults 18 years and older. This otic solution contains clotrimazole, an antifungal medication that targets fungal ear infections caused by:
- Aspergillus species
- Candida species.
Key Features of Clotic Ear Drops
- Generic name: Clotrimazole ear drops
- Use: Fungal otitis externa
- Eligibility: Adults 18+
- Administration: Twice-daily application
- Course length: 14 days
- FDA approval: September 26, 2025
- Formulation: Single-dose vial
- Drug class: Azole antifungal agent
How Clotic Works: Mechanism of Action
Clotic contains clotrimazole, an azole antifungal agent that works by:
- Blocking fungal enzyme production that fungi need to survive
- Damaging fungal cell walls, causing the cells to break down and die
- Disrupting fungal growth by interfering with essential cell processes.
Who Can Use Clotic? Indications and Patient Eligibility
Approved For:
- Adults 18 years of age and older
- Patients with fungal otitis externa (otomycosis)
- Infections caused by Aspergillus and Candida species
- Patients with intact eardrums (tympanic membranes)
NOT Recommended For:
- Children under 18 years of age
- Patients with perforated eardrums (ruptured tympanic membranes)
Contraindications:
Do not use Clotic if:
- You are allergic to clotrimazole or any ingredients in Clotic
- Check the ingredient list at the end of this guide.
Important: Clotic has only been studied in patients with intact tympanic membranes. Its safety and effectiveness in patients with perforated eardrums have not been established.
Clotic Side Effects: What to Expect
Common Side Effects
The most frequently reported side effects of Clotic include:
- Headache
- Application site pain (ear discomfort)
- Eardrum perforation (ruptured tympanic membrane)
- Tinnitus (ringing in the ears)
- Paresthesia (tingling, tickling, or burning sensation).
Important: This is not a complete list of side effects. Contact your healthcare provider if you experience any concerning symptoms. You may report side effects to the FDA at 1-800-FDA-1088.
Before Using
Before using Clotic, tell your healthcare provider about all of your medical conditions, including if you:
- Have had a perforated eardrum or eardrum damage
- Are pregnant or plan to become pregnant. It is not known if Clotic will harm your unborn baby
- Are breastfeeding or plan to breastfeed. It is not known if Clotic can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.
How to Use Clotic: Dosage and Administration Instructions
Read the detailed Instructions for Use that come with Clotic.
- Use Clotic exactly as your healthcare provider tells you to use it.
- Clotic is for use in the ear only (otic use).
- Clotic comes as a liquid in single-dose vials.
- Warm the dose of Clotic by holding the vial in your hand for 1 to 2 minutes to prevent dizziness.
- Apply the entire dose of Clotic from a single-dose vial into the affected ear 2 times a day.
- Each dose should be about 12 hours apart.
- If your symptoms do not improve after 14 days of treatment with Clotic, call your healthcare provider
Clotic Dosing Schedule for Fungal Ear Infections
Standard Dosage:
- Target: Affected ear only
- Frequency: 2 times daily (every 12 hours)
- Duration: 14 days
- Amount: Entire contents of 1 single-dose vial per application
- Total daily use: 2 single-dose vials per day.
Step-by-Step Application Instructions
- Warm the medication. Hold the vial in your hand for 1-2 minutes before use to prevent dizziness
- Open single-dose vial. Use immediately after opening
- Apply the entire dose. Instill the complete contents into the affected ear
- Maintain the dosing schedule. Space your doses approximately 12 hours apart
- Complete the full course. Continue treatment for the full 14 days
- Discard the vial. Throw away the single-dose vial after each use
When to Call Your Doctor
- Symptoms do not improve after 14 days of treatment
- Symptoms worsen during treatment
- New symptoms develop
What Other Drugs Will Affect Clotic?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your
healthcare provider and pharmacist when you get a new medicine.
Storage Instructions for Clotic
Temperature Requirements:
- Store at room temperature: 68°F to 77°F (20°C to 25°C)
- Keep in original carton
Humidity Protection:
- Do not open the foil pouch until ready to use
- Keep unused vials in the foil pouch to protect from humidity
- Discard unused vials 30 days after first opening pouch
Single-Dose Vial Handling:
- Use immediately after opening
- Throw away the vial after use - do not save or reuse
Expiration Date:
- Do not use after expiration date (EXP) on carton, pouch, and vial
- Date format example: 2025-DEC means expires December 31, 2025
Safety:
- Keep Clotic and all medicines out of reach of children
Clotic Ingredients
Active Ingredient: Clotrimazole (antifungal agent)
Inactive Ingredient: Polyethylene glycol 400 (PEG 400)
Manufacturer Information
Clotic is manufactured for Laboratorios Salvat, S.A., and is manufactured by Pharmaloop, S.L. Pol. Industrial Azque – c/ Bolivia, 15 Alcalá de Henares, 28806 Madrid.
Frequently Asked Questions About Clotic
What is fungal otitis externa (otomycosis)?
A fungal infection of the outer ear canal caused by Aspergillus or Candida species.
How long does Clotic treatment take?
14 days of twice-daily treatment (2 vials per day).
Can children use Clotic?
No, Clotic is only approved for adults 18 years and older.
Can I use Clotic if I have a perforated eardrum?
No, Clotic is not recommended for patients with perforated tympanic membranes.
Why do I need to warm the vial?
Warming Clotic prevents dizziness when applied to the ear. When cold drops enter the ear, they can affect your inner ear's balance center, potentially causing temporary lightheadedness or vertigo
References
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.