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Generic name: belladonna alkaloids/methenamine/methylene blue/phenyl salicylate [ bell-a-DON-a/meth-EN-a-meen/METH-i-leen/FEN-ill-sa-LI-si-late ]
Brand name: Examples include Urised and Usept

Urised is used for:

Treating painful and irritating symptoms of the urinary tract due to urinary tract infections or diagnostic procedures.

Urised is a urinary antiseptic, analgesic, and anticholinergic combination. It works by helping to kill bacteria in the urine, decreasing pain and inflammation, and reducing muscle spasms in the urinary tract. These actions work together to help relieve discomfort while urinating.

Do NOT use Urised if:

  • you are allergic to any ingredient in Urised
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin, other salicylate medicines, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)
  • you have angle-closure glaucoma, problems with your esophagus, bowel motility problems, a blockage of your bladder or bowel, severe intestinal problems (eg, ulcerative colitis), severe bleeding, flu or chickenpox, myasthenia gravis, severe kidney problems, or you are severely dehydrated
  • you are taking a sulfonamide (eg, sulfamethizole)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Urised:

Some medical conditions may interact with Urised. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have constipation, diarrhea, an infection of the stomach or bowel, a hiatal hernia, or stomach ulcers
  • if you have nervous system problems, glucose-6-phosphate-dehydrogenase (G-6-PD) deficiency, gout, influenza, Kawasaki syndrome, rheumatic disease, open-angle glaucoma, risk factors for angle-closure glaucoma, kidney or liver problems, an enlarged prostate, bladder problems, or you are unable to urinate
  • if you have a history of stroke or brain blood vessel problems (eg, aneurysm), an irregular heartbeat, heart blood vessel problems, congestive heart failure, heart valve problems, or other heart problems
  • if you are on a low-salt diet

Some MEDICINES MAY INTERACT with Urised. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine) because the side effects of Urised may be increased
  • Ketoconazole because the effectiveness of Urised may be decreased
  • Monoamine oxidase (MAO) inhibitors or narcotic pain medicine (eg, codeine) because the risk of serious side effects may be increased
  • Medicine for myasthenia gravis (eg, ambenonium), phenothiazines (eg, chlorpromazine), sulfonamides (eg, sulfamethizole), thiazide diuretics (eg, hydrochlorothiazide), or urinary alkalinizers (eg, sodium bicarbonate) because effectiveness may be decreased by Urised

This may not be a complete list of all interactions that may occur. Ask your health care provider if Urised may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Urised:

Use Urised as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Urised may be taken with or without food.
  • Do not take antacids or antidiarrheal medicines (eg, loperamide) within 1 hour before or after taking Urised.
  • Drink plenty of fluids while taking Urised.
  • If you miss a dose of Urised, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Urised.

Important safety information:

  • Urised may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Urised. Using Urised alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not take Urised more often or in larger amounts than prescribed by your health care provider.
  • Urised may discolor the urine or feces a blue-green color. This is normal and not a cause for concern.
  • Urised contains an aspirin-like medicine, which has been linked to Reye syndrome. Do not give Urised to children or teenagers during or after chickenpox, flu, or other viral infections without checking with your doctor or pharmacist.
  • Use Urised with caution in the ELDERLY because they may be more sensitive to its effects, especially excitement, agitation, drowsiness, and confusion.
  • Urised is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Urised can cause harm to the fetus. If you become pregnant while taking Urised, discuss with your doctor the benefits and risks of using Urised during pregnancy. Urised is excreted in breast milk. If you are or will be breast-feeding while you are using Urised, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Urised:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry mouth; flushing; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; difficulty urinating; dizziness; fast or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Urised:

Store Urised at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Urised out of the reach of children and away from pets.

General information:

  • If you have any questions about Urised, please talk with your doctor, pharmacist, or other health care provider.
  • Urised is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Urised. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.