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Prinzide

Generic name: lisinopril/hydrochlorothiazide [ lye-SIN-oh-pril/HYE-droe-KLOR-oh-THYE-a-zide ]
Brand name: Examples include Prinzide and Zestoretic

Prinzide may cause injury or death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.


Prinzide is used for:

Treating high blood pressure.

Prinzide is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works by removing excess fluid from the body and causing blood vessels to relax or widen.

Do NOT use Prinzide if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prinzide:

Some medical conditions may interact with Prinzide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Prinzide. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prinzide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prinzide:

Use Prinzide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Prinzide.

Important safety information:

Possible side effects of Prinzide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; light-headedness; nonproductive cough; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blurred vision or other vision changes (eg, decreased vision clearness); change in the amount of urine produced; chest pain or discomfort; dark urine; difficult or painful urination; drowsiness; dry mouth; eye pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; joint pain, stiffness, or swelling; loss of appetite; mood or mental changes (eg, depression); muscle cramps, pain, or weakness; numbness, burning, or tingling; numbness of an arm or leg; one-sided weakness; pale stools; persistent or unusual nausea or vomiting; red, swollen, blistered, or peeling skin; restlessness; severe or persistent cough; severe or persistent headache, dizziness, or light-headedness; shortness of breath; slurred speech; stomach pain (with or without nausea or vomiting); sudden, unusual weight loss or gain; symptoms of high blood sugar (eg, fast breathing; flushing; fruit-like breath odor; increase in thirst, hunger, or urination); symptoms of low blood sodium (eg, confusion, mental or mood changes, seizures, sluggishness); trouble swallowing; unusual bruising or bleeding; unusual thirst, weakness, or tiredness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or light-headedness; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle cramps, pain, or weakness; seizures; sluggishness); symptoms of dehydration (eg, drowsiness; dry eyes; fast heartbeat; nausea; restlessness; unusual thirst, tiredness, or weakness; vomiting).

Proper storage of Prinzide:

Store Prinzide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in bathroom. Keep Prinzide out of the reach of children and away from pets.

General information:

This information should not be used to decide whether or not to take Prinzide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Prinzide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Prinzide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Prinzide.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.