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Ticarcillin and Clavulanic Acid use while Breastfeeding

Ticarcillin and Clavulanic Acid Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information is available on the use of ticarcillin and clavulanic acid during breastfeeding, limited information indicates that maternal doses of ticarcillin 15 grams daily produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated. The combination of ticarcillin and clavulanic acid is acceptable to use during breastfeeding.

Drug Levels

Maternal Levels. No studies on the combination of ticarcillin and clavulanic acid during breastfeeding have been reported. Only trace levels of ticarcillin were detected for 6 hours after single 1 gram intramuscular doses in 3 women in one study[1][2] and 5 women in another early study.[3]

After ticarcillin doses of 5 grams intravenously three times a day in 10 women, milk levels averaged 2 to 2.5 mg/L. By 12 hours after the last dose, ticarcillin was undetectable in the milk. The total daily intake of a breastfed infant would be negligible.[4]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Matsuda S, Tanno M, Kashiwakura T et al. Laboratory and clinical use of ticarcillin. Chemotherapy (Tokyo). 1977;25:2924-31.

2. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

3. Cho N, Nakayama T, Uehara K et al. Laboratory and clinical evaluation of ticarcillin in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1977;25:2911-23.

4. von Kobyletzki D, Dalhoff A, Lindemeyer H et al. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983;11:144-9. PMID: 6885173

Ticarcillin and Clavulanic Acid Identification

Substance Name

Ticarcillin and Clavulanic Acid

CAS Registry Number

86482-18-0

Drug Class

Antiinfective Agents

Antibacterial Agents

Penicillins

Administrative Information

LactMed Record Number

257

Last Revision Date

20150310

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Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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