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Lanolin use while Breastfeeding

Drugs containing Lanolin: Lanolin Hydrous, Lansinoh for Breast Feeding Mothers, Lantiseptic Dry Skin Therapy, Lantiseptic Original Skin Protectant, Tender Care, Lanolor Cream, Lansinoh for Healthy Feet, Soothe and Cool Free Medseptic Skin Protectant, Lan-O-Soothe, Alpha Keri, Show all 13 »Thera Derm, AlphaBath, Eucerin Unscented

Medically reviewed by Last updated on Nov 8, 2020.

Lanolin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Lanolin is a yellow fat obtained from sheep's wool. It has traditionally been used topically to treat sore, cracked nipples during breastfeeding. Highly purified modified lanolin (Lansinoh) has the pesticide and detergent residues removed and the natural free alcohols reduced to below 1.5% to improve safety and reduce the allergic potential.[1] However, it should be avoided in patients with a known allergy to wool.

Although lanolin appears to be effective for the prevention and treatment of nipple pain during breastfeeding,[2] but not preventative use initiated before delivery.[3] Studies, most of which used Lansinoh, have not found lanolin to be consistently different in efficacy from application of breastmilk, hydrogel dressings, peppermint gel, aloe vera or warm compresses.[4-10] A metaanalysis concluded that application of nothing or breastmilk may be superior to lanolin, but good studies are lacking.[11] One small nonblinded study found olive oil to be superior to lanolin for prevention of sore nipples,[12] and another small, single-blinded study found that lanolin application to painful nipples did not decrease nipple pain compared to usual care.[13] A study in women with nipple trauma and pain comparing application of lanolin after each feeding to application of breastmilk plus a nipple shell found that the breastmilk and shell were more effective than lanolin.[14] A randomized study comparing highly purified lanolin (Lansinoh) to expressed breastmilk in 180 mothers, found lanolin to be superior to breastmilk over a 7-day period in reducing pain and the nipple trauma score.[15]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

In a randomized, double-bind trial, lanolin was compared to an all-purpose nipple ointment containing mupirocin 1%, betamethasone 0.05%, and miconazole 2% for painful nipples while nursing in the first 2 weeks postpartum. The two treatments were equally effective in reducing nipple pain, nipple healing time, breastfeeding duration, breastfeeding exclusivity rate, mastitis and nipple symptoms, side effects or maternal satisfaction with treatment.[16]

A randomized trial in nursing women with damaged, painful nipples compared lanolin application to usual care, which was a variable mix of education or assistance by health professional, application of warm or cool compresses, analgesics, air drying the nipples or the use of breast shields. A blinded observer assessed healing via telephone calls to the mothers several times after randomization. No differences were found in nipple pain between the groups 4 to 7 days after randomization. No difference was found in breastfeeding self-efficacy at 4 days post-randomization or in the breastfeeding rates of the two groups at 4 and 12 weeks postpartum. Patient satisfaction with care was higher in the women who received lanolin.[13]


Mohammadzadeh A, Farhat A, Esmaeily H. The effect of breast milk and lanolin on sore nipples. Saudi Med J. 2005;26:1231–4. [PubMed: 16127520]
Vieira F, Bachion MM, Mota DD, et al. A systematic review of the interventions for nipple trauma in breastfeeding mothers. J Nurs Scholarsh. 2013;45:116–25. [PubMed: 23452043]
Oliveira FS, Vieira F, Guimarães JV, et al. Lanolin and prenatal health education for prevention of nipple pain and trauma: Randomized clinical trial. Enferm Clin. 2020 [PubMed: 33277168]
Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: A systematic review. J Obstet Gynecol Neonatal Nurs. 2005;34:428–37. [PubMed: 16020410]
Melli MS, Rashidi MR, Nokhoodchi A, et al. A randomized trial of peppermint gel, lanolin ointment, and placebo gel to prevent nipple crack in primiparous breastfeeding women. Med Sci Monit. 2007;13:CR406–11. [PubMed: 17767120]
Abou-Dakn M, Fluhr JW, Mo G, et al. Positive effect of HPA lanolin versus expressed breastmilk on painful and damaged nipples during lactation. Skin Pharmacol Physiol. 2011;24:27–35. [PubMed: 20720454]
Shanazi M, Farshbaf Khalili A, Kamalifard M, et al. Comparison of the effects of lanolin, peppermint, and dexpanthenol creams on treatment of traumatic nipples in breastfeeding mothers. J Caring Sci. 2015;4:297–307. [PMC free article: PMC4699508] [PubMed: 26744729]
Dodd V, Chalmers C. Comparing the use of hydrogel dressings to lanolin ointment with lactating mothers. J Obstet Gynecol Neonatal Nurs. 2003;32:486–95. [PubMed: 12903698]
Pugh LC, Buchko BL, Bishop BA, et al. A comparison of topical agents to relieve nipple pain and enhance breastfeeding. Birth. 1996;23:88–93. [PubMed: 8826172]
Saeidi R, Tafazoli M, Gholami M, et al. New treatment for nipple soreness in breastfeeding mothers: A clinical trial study. Iran J Neonatol 2015;6:48-51. http://ijn​​/issue_626_671_Volume+6​%2C+Issue+2%2C+Spring+2015.html.
Dennis CL, Jackson K, Watson J. Interventions for treating painful nipples among breastfeeding women. Cochrane Database Syst Rev. 2014;12:CD007366. [PubMed: 25506813]
Gungor AN, Oguz S, Vurur G, et al. Comparison of olive oil and lanolin in the prevention of sore nipples in nursing mothers. Breastfeed Med. 2013;8:334–5. [PubMed: 23249138]
Jackson KT, Dennis CL. Lanolin for the treatment of nipple pain in breastfeeding women: A randomized controlled trial. Matern Child Nutr. 2017;13:e12357. [PMC free article: PMC6865977] [PubMed: 27477840]
Vieira F, Mota DD, Castral TC, et al. Effects of anhydrous lanolin versus breast milk combined with a breast shell for the treatment of nipple trauma and pain during breastfeeding: A randomized clinical trial. J Midwifery Womens Health. 2017;62:572–9. [PubMed: 28887855]
Mariani Neto C, de Albuquerque RS, de Souza SC, et al. Comparative study of the use of HPA lanolin and breast milk for treating pain associated with nipple trauma. Rev Bras Ginecol Obstet. 2018;40:664–72. [PubMed: 30372779]
Dennis CL, Schottle N, Hodnett E, et al. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: A randomized controlled trial. Breastfeed Med. 2012;7:473–9. [PubMed: 22428572]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding



Pharmaceutic Aids


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Further information

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