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Diphenoxylate use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on Feb 2, 2025.

Drugs containing Diphenoxylate: Lomotil, Vi-Atro, Lomanate, Logen, Lomocot, Lonox

Diphenoxylate Levels and Effects while Breastfeeding

Summary of Use during Lactation

No data exist on the use of diphenoxylate during breastfeeding. One expert panel considers diphenoxylate to be unacceptable during breastfeeding while another found it to be potentially toxic.[1,2] Based on its chemical and pharmacological similarity to narcotics, occasional small doses of diphenoxylate may be acceptable while breastfeeding an older infant, but alternatives are preferred, especially while nursing a newborn.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Loperamide

References

1.
Lewis JH, Weingold AB and the Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol 1985;80:912-23. [PubMed: 2864852]
2.
Mahadevan U, Kane S. American Gastroenterological Association Institute Technical Review on the Use of Gastrointestinal Medications in Pregnancy. Gastroenterology 2006;131:283-311. [PubMed: 16831611]

Substance Identification

Substance Name

Diphenoxylate

CAS Registry Number

915-30-0

Drug Class

Breast Feeding

Lactation

Milk, Human

Antidiarrheals

Gastrointestinal Agents

Narcotics

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

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