Diphenoxylate use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on Feb 2, 2025.
Drugs containing Diphenoxylate: Lomotil, Vi-Atro, Lomanate, Logen, Lomocot, Lonox
Diphenoxylate Levels and Effects while Breastfeeding
Summary of Use during Lactation
No data exist on the use of diphenoxylate during breastfeeding. One expert panel considers diphenoxylate to be unacceptable during breastfeeding while another found it to be potentially toxic.[1,2] Based on its chemical and pharmacological similarity to narcotics, occasional small doses of diphenoxylate may be acceptable while breastfeeding an older infant, but alternatives are preferred, especially while nursing a newborn.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
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Lewis JH, Weingold AB and the Committee of FDA-Related Matters American College of Gastroenterology. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol 1985;80:912-23. [PubMed: 2864852]
- 2.
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Mahadevan U, Kane S. American Gastroenterological Association Institute Technical Review on the Use of Gastrointestinal Medications in Pregnancy. Gastroenterology 2006;131:283-311. [PubMed: 16831611]
Substance Identification
Substance Name
Diphenoxylate
CAS Registry Number
915-30-0
Drug Class
Breast Feeding
Lactation
Milk, Human
Antidiarrheals
Gastrointestinal Agents
Narcotics
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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- Drug Levels and Effects
- Substance Identification
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.