Benzalkonium Chloride use while Breastfeeding
Drugs containing Benzalkonium Chloride: Merthiolate, Benza, A + D Cracked Skin Relief, Mercuroclear, First Aid Antiseptic, Herpetrol, Neosporin Neo To Go!, Dr Scholl's Cracked Heel Relief, Tanac, CureChrome, Show all 13 »HandClens 2 in 1, Zephiran Chloride, Pedi-Pro (Benzalkonium)
Benzalkonium Chloride Levels and Effects while Breastfeeding
Summary of Use during Lactation
Topical maternal application of benzalkonium chloride or benzethonium chloride or their presence as a preservative in pharmaceuticals would not be expected to cause any adverse effects in breastfed infants.
Johnson W Jr. Final report on the safety assessment of benzalkonium chloride. J Am Coll Toxicol. 1989;8:589-625.
Effects in Breastfed Infants
A study in Japan randomized 80 consecutive term patients into 4 groups who received either povidone-iodine or benzethonium chloride as a skin disinfectant before delivery and one of these for postpartum vaginal lacerations. Prepartum doses were about 7 mL and postpartum doses were about 0.5 mL of solution. Infant thyrotropin levels were elevated in the infants whose mothers received topical povidone-iodine pre- and postpartum compared to infants whose mothers received benzethonium chloride.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
1. Johnson W Jr. Final report on the safety assessment of benzalkonium chloride. J Am Coll Toxicol. 1989;8:589-625.
2. Koga Y, Sano H, Kikukawa Y et al. Affect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol. 1995;21:581-5. PMID: 8640469
Benzalkonium Chloride Identification
CAS Registry Number
Antiinfective Agents, Local
LactMed Record Number
Last Revision Date
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