Antipyrine use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on Apr 15, 2024.
Drugs containing Antipyrine: Auralgan, Allergen, Aurax, Otogesic, Otic Edge, Treagan, PR Otic, Otic Care, OtiLam, Auroto, Show all 20 »A/B Otic, Otigesic, Rx-Otic, Aurodex, Aurogard, Dolotic, Tympagesic, Chlorphenylcaine, Otozin, Neotic
Antipyrine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Antipyrine is considered unlikely to harm the infant.[1] Because antipyrine is available in the US only in ear drops, it is unlikely to be absorbed by the mother and reach the breastmilk. No special precautions are required during maternal use of antipyrine-containing ear drops.
Drug Levels
Maternal Levels. Antipyrine was given to 7 lactating women who were 2 to 19 months postpartum. Each woman drank a single oral dose of 18 mg/kg of antipyrine in solution. Peak milk levels usually occurred 10 minutes after ingestion and ranged from about 10 to 30 mg/L. The antipyrine half-life in milk averaged 11.6 hours (range 5.7 to 21.7 hours). The authors estimated that a fully breastfed infant would ingest 6.4 mg of antipyrine after this maternal dose or 0.59% of the maternal dose (not weight-adjusted). Two of the women who were studied before and after pregnancy indicated that antipyrine clearance might be increased by about two-fold during lactation.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
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Berlin CM Jr, Vesell S. Antipyrine disposition in milk and saliva of lactating women. Clin Pharmacol Ther. 1982;31:38–44. [PubMed: 7053302]
Substance Identification
Substance Name
Antipyrine
CAS Registry Number
60-80-0
Drug Class
Breast Feeding
Lactation
Anti-Inflammatory Agents, Non-Steroidal
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- Drug Levels and Effects
- Substance Identification
Further information
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