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Publicly Funded Cancer Trials Gained Americans 3 Million More Years

Posted 16 days ago by Drugs.com

TUESDAY, June 6, 2017 – Public-funded trials have significantly extended the lives of people diagnosed with cancer, according to new research. SWOG, the clinical trials network funded by the U.S. National Cancer Institute (NCI), has involved more than 200,000 patient volunteers. These trials have led to approval of 14 new cancer drugs and more than 100 changes to cancer care standards. All told, the clinical trials studied extended life by 3.34 million years, the study found. SWOG estimates the dollar return on investment from federal funding at $125 for each year of life gained. "A lot of people with cancer have lived longer because of the therapies tested in our publicly funded trials," study leader Joseph Unger said in a SWOG news release. He is an assistant member of the Fred Hutchinson Cancer Research Center's Cancer Prevention Program in Seattle. "At the same time, the cost of ... Read more

Related support groups: Cancer, Depo-Provera, Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Prostate Cancer, Medroxyprogesterone, Tamoxifen, Arimidex, Fluorouracil, Tretinoin, Lupron Depot, Femara, Gleevec, Colorectal Cancer, Rituxan, Lung Cancer, Isotretinoin

'Cooling Caps' May Halt Chemo-Linked Hair Loss

Posted 14 Feb 2017 by Drugs.com

TUESDAY, Feb. 14, 2017 – Scalp cooling caps can help breast cancer patients save their hair from the ravages of chemotherapy, a pair of new studies suggests. More than half of women fitted with cooling caps kept their hair during chemotherapy in the world's first randomized clinical trial of the devices, said lead researcher Dr. Julie Nangia. She is an assistant professor and breast cancer expert with the Baylor College of Medicine in Houston. "The trial was stopped early because the device was so effective in the group that got the device," Nangia said. "In our study, half of women who used the scalp cooling device kept their hair, and in the control group there was zero percent hair retention. Everyone who didn't have the device lost their hair." A second study also found that the cooling caps could reduce hair loss, with two-thirds of patients losing half or less of their hair ... Read more

Related support groups: Cancer, Breast Cancer, Colorectal Cancer, Breast Cancer, Metastatic, Herceptin, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Tykerb, Kadcyla, Perjeta, Pertuzumab, Trastuzumab, Lapatinib, Ado-trastuzumab Emtansine

Half Report Severe Side Effects From Breast Cancer Therapy

Posted 24 Jan 2017 by Drugs.com

TUESDAY, Jan. 24, 2017 – About half of early stage breast cancer patients experience severe side effects from their treatment, a new study finds. "It's in patients' best interest to receive their treatments on time and on schedule, whenever possible, to give them the best possible outcome," said study author Dr. Steven Katz. He's professor of health management and policy at the University of Michigan. "Unscheduled care for toxicities [side effects] – including clinic visits, emergency department visits and hospital stays – are expensive, inconvenient and disruptive to both doctors and patients. We need to avoid them whenever possible," Katz said in a university news release. For the study, researchers surveyed almost 2,000 early stage breast cancer patients an average of seven months after diagnosis. The women were asked to rate the severity of seven common treatment side effects: ... Read more

Related support groups: Surgery, Breast Cancer, Fluorouracil, Efudex, Breast Cancer, Metastatic, Carac, Herceptin, Taxol, Breast Cancer - Adjuvant, Taxotere, Carboplatin, Cytoxan, Breast Cancer, Prevention, Cyclophosphamide, Paclitaxel, Doxorubicin, Adriamycin, Breast Cancer - Palliative, Fluoroplex, Docetaxel

'Chemo Brain' Lasts for Months in Many Breast Cancer Survivors

Posted 11 Jan 2017 by Drugs.com

WEDNESDAY, Jan. 11, 2017 – "Chemo brain" – the mental fog common after breast cancer treatment – can persist for six months, new research shows. The finding comes from one of the largest studies to date to look at chemotherapy-related thinking problems that plague many women treated for breast cancer. Those problems can include memory lapses, attention issues and difficulty processing information. When researchers compared hundreds of U.S. women six months after chemotherapy ended with hundreds of healthy women, they found more than one-third of the chemotherapy group had a decline in thinking scores versus less than 15 percent of the others. "The bottom line is, this is a real problem, patients are having difficulties and we need to acknowledge it is one of the difficulties of treatment," said Dr. Patricia Ganz. Ganz is director of cancer prevention and control research at the ... Read more

Related support groups: Cancer, Depo-Provera, Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Zoladex, Evista, Megestrol, Megace, Herceptin, Afinitor, Aromasin

Study Casts More Doubt on Value of Mammograms

Posted 10 Jan 2017 by Drugs.com

MONDAY, Jan. 9, 2017 – Mammograms frequently detect small breast tumors that might never become life-threatening, causing women to receive treatment they likely don't need, a new Danish study finds. About one in every three women between the ages of 50 and 69 who was diagnosed with breast cancer wound up having a tumor that posed no immediate threat to her health, the researchers reported. At the same time, mammography did not reduce the number of advanced breast cancers found in women in the study. "This means that breast screening is unlikely to improve breast cancer survival or reduce the use of invasive surgery," said study author Dr. Karsten Juhl Jorgensen, deputy director of research for the Nordic Cochrane Center at the Rigshospitalet in Copenhagen. "It also means that breast screening leads to unnecessary detection and treatment of many breast cancers." Dr. Otis Brawley, chief ... Read more

Related support groups: Depo-Provera, Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Anastrozole, Letrozole, Zoladex, Megestrol, Evista, Megace, Herceptin, Aromasin, Exemestane, Casodex, Eligard

Breast Cancer Cells May Change When They Spread to Brain: Study

Posted 7 Dec 2016 by Drugs.com

WEDNESDAY, Dec. 7, 2016 – When breast cancer spreads to the brain, important molecular changes may occur in the cancer, a small study found. The discovery of these changes could lead to improved diagnosis and treatment, the researchers said. About 20 percent of breast cancers are a type known as HER2-positive, which typically respond to targeted therapies. However, HER2-negative breast cancer that has spread to the brain doesn't respond to the same therapies. In this study, researchers analyzed tumors from 20 patients in the United States and Ireland. They found that primary breast cancer identified as HER2-negative switched to HER2-positive when it spread to the brain. The findings show that treatments should target not only the original breast cancer, but also brain tumors, said study author Adrian Lee, director of the Institute for Precision Medicine, part of the University of ... Read more

Related support groups: Breast Cancer, Estradiol, Premarin, Ethinyl Estradiol, Estrace, Arimidex, Femara, Vagifem, Estrace Vaginal Cream, Breast Cancer, Metastatic, Vivelle, Anastrozole, Climara, Letrozole, Estring, Vivelle-Dot, Premarin Vaginal, Herceptin, Estradiol Patch, Aromasin

Intense Chemo Offers Little Benefit for Early Breast Cancer: Study

Posted 9 Nov 2016 by Drugs.com

WEDNESDAY, Nov. 9, 2016 – A more intense type of chemotherapy offers little benefit over standard chemotherapy for women with high-risk early breast cancer, European researchers report. Known as tailored dose-dense chemotherapy, the treatments are given over a shorter period of time without increasing the overall dose. It has been suggested as a way to improve the effectiveness of the treatment for early breast cancer. However, the European study did not find a difference in recurrence-free survival or overall survival after five years of follow-up. The investigators did find that the dose-dense group had better event-free survival, defined as the time to any breast cancer relapse, cancer in the opposite breast, other malignant growths or death from any cause. Despite the results, a U.S. breast cancer expert said there is still a role for the approach in certain women. Researchers from ... Read more

Related support groups: Depo-Provera, Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Zoladex, Evista, Megestrol, Megace, Herceptin, Aromasin, Exemestane, Casodex

Cancer's Heavy Financial Burden

Posted 8 Jun 2016 by Drugs.com

WEDNESDAY, June 8, 2016 – Many cancer patients can't afford to see their doctor or take the medications they've been prescribed, a new study finds. And the problem will likely only get worse as the cost of cancer treatments continues to rise, the study authors said. "You can prescribe the best drug in the world, but if patients can't afford it and they can't get it, then it won't be effective," said study author Dr. Greg Knight. He is chief fellow with the University of North Carolina School of Medicine's division of hematology and oncology. "We saw a significant portion of patients in our study who were stretching their prescriptions or not coming to the doctor's office," Knight said in a university news release. The researchers reviewed survey results from nearly 2,000 patients at the N.C. Cancer Hospital in Chapel Hill, N.C. The participants were all 18 and older, and had been ... Read more

Related support groups: Cancer, Breast Cancer, Prostate Cancer, Gleevec, Colorectal Cancer, Lung Cancer, Votrient, Brain Tumor, Tarceva, Avastin, Melanoma, Skin Cancer, Tasigna, Ovarian Cancer, Endometrial Cancer, Sutent, Herceptin, Afinitor, Sprycel, Nausea/Vomiting - Chemotherapy Induced

U.S. Pays Highest Prices for Cancer Meds: Study

Posted 6 Jun 2016 by Drugs.com

MONDAY, June 6, 2016 – The United States pays the highest prices in the world for generic and brand-name cancer drugs, a new study has found. However, as the world's wealthiest nation, the United States is better able to pay for those pricey drugs than poorer countries with somewhat lower medication prices, added study lead author Dr. Daniel Goldstein. People in China and India are much less able to afford cancer drugs than Americans, he said, even though U.S. monthly drug prices are about three to six times higher in the United States. That doesn't mean America came out on top in overall drug affordability, however. Developed nations such as Australia, England and Israel had the "best deal" in the world on cancer drugs, thanks to government programs that regulate drug pricing, the study found. "America is the wealthiest nation, but its drug prices are significantly higher – so much ... Read more

Related support groups: Cancer, Depo-Provera, Provera, Methotrexate, Breast Cancer, Accutane, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Fluorouracil, Tretinoin, Lupron Depot, Femara, Gleevec, Colorectal Cancer, Rituxan, Lung Cancer, Isotretinoin, Votrient

Cheaper Breast Cancer Drug Does Well in Clinical Trial

Posted 4 Jun 2016 by Drugs.com

FRIDAY, June 3, 2016 – For women with advanced HER2-positive breast cancer, a similar but less expensive experimental drug works just as well as the standard drug Herceptin (trastuzumab), a new study finds. HER2-positive tumors contain certain genes that are associated with more rapid tumor growth and a worse prognosis, according to the American Cancer Society. The new drug targeting these tumors is what's known as a biosimilar drug – in this case, a drug similar to Herceptin. Biosimilars are designed to mimic the brand-name medicine, and are expected to produce roughly the same results in patients, the U.S. Food and Drug Administration explained. Researchers conducted a randomized phase III clinical trial of the biosimilar trastuzumab antibody drug MYL-1401O. Their trial included 500 patients. The trial was conducted at 95 sites in Africa, Asia, Europe and Latin America. The women ... Read more

Related support groups: Breast Cancer, Breast Cancer, Metastatic, Herceptin, Breast Cancer - Adjuvant, Breast Cancer, Prevention, Diagnosis and Investigation, Breast Cancer - Palliative, Trastuzumab

'Precision' Cancer Treatment May Extend Lives

Posted 20 May 2016 by Drugs.com

THURSDAY, May 19, 2016 – "Precision" cancer treatment that's guided by genetic clues from the patient's own tumor appears to outperform traditional chemotherapy, a new research review finds. Patients given precision – or personalized – treatment experienced a tumor shrinkage rate six times that attained by regular chemotherapy. But, that only happened if doctors used genetic information to choose the appropriate targeted therapy, said lead researcher Maria Schwaederle. Those patients also experienced nearly double the length of time before their cancer resumed growing, according to the analysis of nearly 350 clinical trials. "It is not just that the therapies are better, but that targeted therapies must be given to the right patients," said Schwaederle, who's with the University of California, San Diego School of Medicine's Center for Personalized Cancer Therapy. She will present ... Read more

Related support groups: Cancer, Methotrexate, Breast Cancer, Accutane, Fluorouracil, Tretinoin, Gleevec, Colorectal Cancer, Lung Cancer, Isotretinoin, Claravis, Tarceva, Skin Cancer, Xeloda, BCG, Tasigna, Revlimid, Zytiga, Herceptin, Hydroxyurea

Could Talk Therapy Ease Chemo-Related Memory Issues?

Posted 2 May 2016 by Drugs.com

MONDAY, May 2, 2016 – A type of psychotherapy might help cancer survivors deal with the long-term thinking problems some experience after chemotherapy, researchers say. It's estimated that about half of those who undergo chemotherapy for cancer develop what's often called "chemo brain." For instance, they may have trouble following conversations or remembering the steps in a project, according to background notes with the new study. Although usually mild, these changes can affect quality of life, job performance and relationships, said the researchers from the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine. The researchers developed a cognitive-behavioral therapy (CBT) program called Memory and Attention Adaptation Training to help cancer survivors prevent or manage these memory problems. Their study involved 47 breast cancer survivors who underwent ... Read more

Related support groups: Cancer, Methotrexate, Breast Cancer, Prostate Cancer, Fluorouracil, Gleevec, Colorectal Cancer, Lung Cancer, Renal Cell Carcinoma, Non-Small Cell Lung Cancer, Breast Cancer, Metastatic, Brain Tumor, Melanoma, Pancreatic Cancer, Xeloda, Skin Cancer, Tasigna, Ovarian Cancer, Endometrial Cancer, Herceptin

Drug Duo May Rapidly Shrink Breast Tumors in Some Patients

Posted 10 Mar 2016 by Drugs.com

THURSDAY, March 10, 2016 – A two-drug combo quickly shrinks certain breast cancer tumors before surgery or chemotherapy in some women, British researchers report. The specific breast cancer is called human epidermal growth factor receptor 2 (HER2) positive. The drug combination – lapatinib (Tykerb) and trastuzumab (Herceptin) – shrank HER2-positive tumors significantly in less than two weeks after diagnosis, the study authors said. In some cases, evidence of the cancers disappeared, the researchers added. "A combination of two anti-HER2 therapies – Tykerb and Herceptin – induce tumor regression or disappearance in 25 percent of HER2-positive cancers in 11 days," said lead researcher Dr. Nigel Bundred. He is a professor of surgical oncology at the University of Manchester in England. Potentially, women who respond to this treatment combination might be able to avoid chemotherapy, he ... Read more

Related support groups: Cancer, Breast Cancer, Breast Cancer, Metastatic, Herceptin, Breast Cancer, Prevention, Breast Cancer - Palliative, Tykerb, Osteolytic Bone Metastases of Breast Cancer, Trastuzumab, Lapatinib

Early Chemo Less Likely to Help Black Breast Cancer Patients: Study

Posted 12 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Early chemotherapy is less likely to benefit black women with breast cancer than those in other racial and ethnic groups, a new study finds. Advanced breast cancer is more common among black, Hispanic and Asian women than it is in white women. As a result, black women often receive chemotherapy before surgery in an effort to improve their outcomes, the Yale University Cancer Center researchers said. But their study of 27,300 women with stage 1 to 3 breast cancer showed that early (neoadjuvant) chemotherapy was less effective in black patients than in other women. "Even when we controlled for the fact that minority women often present with more advanced-stage, higher-grade tumors, and more aggressive types of breast cancer overall, our team was surprised to find that black women did not respond as well to neoadjuvant chemotherapy compared to other racial groups," ... Read more

Related support groups: Depo-Provera, Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Zoladex, Megestrol, Evista, Megace, Herceptin, Aromasin, Exemestane, Casodex

Two Drugs Equal in Preventing Early Breast Cancer's Return: Study

Posted 11 Dec 2015 by Drugs.com

FRIDAY, Dec. 11, 2015 – Postmenopausal women who have an early, noninvasive form of breast cancer had similar recurrence rates of disease whether they took the drug tamoxifen or the aromatase inhibitor anastrozole after surgery, new research shows. However, the side effects of the two medications differed greatly, said study author Jack Cuzick, director of the Wolfson Institute of Preventive Medicine at Queen Mary University of London, England. His team looked at nearly 3,000 women, all past menopause, who had hormone-receptor positive ductal carcinoma in situ (DCIS) breast cancer and underwent surgery to excise it. With DCIS, the cells that line the milk ducts have changed but not spread into the surrounding breast tissue. Half the women were randomly assigned to take 1 milligram (mg) a day of anastrozole (Arimidex), while the other half took 20 mg a day of tamoxifen (Nolvadex). Each ... Read more

Related support groups: Depo-Provera, Provera, Breast Cancer, Lupron, Medroxyprogesterone, Tamoxifen, Arimidex, Lupron Depot, Femara, Breast Cancer, Metastatic, Anastrozole, Letrozole, Zoladex, Megestrol, Evista, Megace, Herceptin, Aromasin, Exemestane, Casodex

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