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Could Red Wine Ingredient Affect Progression of Alzheimer's?

Posted 11 Sep 2015 by Drugs.com

FRIDAY, Sept. 11, 2015 – High doses of resveratrol, a compound found in red wine and berries, may have some activity against Alzheimer's disease, a preliminary clinical trial suggests. Resveratrol is an antioxidant that certain plants produce to shield against stress from the environment. People ingest small amounts when they eat red grapes, red wine, berries or dark chocolate. Lab research has suggested that resveratrol might have some powers against the diseases of aging – including Alzheimer's disease. But evidence from human studies has been lacking. The new study, published Sept. 11 in Neurology, offers the first evidence that high-dose, "pharmaceutical-grade" resveratrol can get into the brains of people with mild to moderate Alzheimer's. What's more, it seems to stabilize levels of a protein that is linked to Alzheimer's progression. The study did not, however, show whether ... Read more

Related support groups: Dementia, Alzheimer's Disease, Mild Cognitive Impairment, Resveratrol

Resveratrol in Red Wine May Not Be Such a Health Booster, After All

Posted 12 May 2014 by Drugs.com

MONDAY, May 12, 2014 – Resveratrol – a substance found in red wine, grapes and chocolate may not add years to your life, and it doesn't appear to reduce the risk for heart disease or cancer either, according to new research. "When it comes to diet, health and aging, things are not simple and probably do not boil down to one single substance, such as resveratrol," said study lead researcher Dr. Richard Semba, a professor of ophthalmology at Johns Hopkins University School of Medicine in Baltimore. The findings also cast doubt about taking resveratrol supplements, he said. "Perhaps it brings us back again to rather tried and true advice of diet – Mediterranean-style – and regular aerobic exercise for healthy aging," said Semba. The report was published May 12 in the online edition of JAMA Internal Medicine. Red wine and chocolate have been shown to have beneficial effects on health, ... Read more

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Red Wine Supplement May Block Benefits of Exercise in Older Men

Posted 25 Jul 2013 by Drugs.com

THURSDAY, July 25 – Although some antioxidants may be good, more may not be better. New research suggests that resveratrol, a natural antioxidant found in red grapes and products derived from them – such as red wine – could offset the health benefits of exercise in older men. The study involved 27 healthy but inactive men, all nonsmokers around 65 years old. The University of Copenhagen researchers had the men engage in high-intensity exercise, which included full-body circuit training, for a total of eight weeks. During this time, half of the participants were given 250 milligrams (mg) of resveratrol daily. The rest of the men received a placebo pill that contained no active ingredients. Neither the researchers nor the men involved in the study knew if they were taking resveratrol or the dummy pill. Although physical activity improved the men's heart health, the study, published ... Read more

Related support groups: Cardiovascular Risk Reduction, Resveratrol

Supplements of Red Wine Antioxidant Don't Help Obese Men

Posted 28 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – Despite showing early promise in some animal studies, supplements of resveratrol, an antioxidant found aplenty in red wine, did not improve insulin sensitivity or heart health in obese men, a small trial found. Researchers found no difference in insulin sensitivity – the measure of how well the body uses the hormone insulin – in 24 obese but otherwise healthy men who took daily 1,500-milligram doses of resveratrol compared to other men who took an inactive placebo for four weeks. Nor were there any changes in other signs of heart health, including blood pressure, levels of blood fats called triglycerides and other fats. The study, led by Dr. Morten Poulsen at Aarhus University Hospital in Denmark, appears online Nov. 28 in the journal Diabetes. Dr. Vivian Fonseca, president of medicine and science for the American Diabetes Association, said he is not surprised ... Read more

Related support groups: Obesity, Resveratrol

Supplement of Red Wine Ingredient Won't Help Healthy Women: Study

Posted 25 Oct 2012 by Drugs.com

THURSDAY, Oct. 25 – Healthy middle-aged women do not benefit from taking resveratrol supplements, new study shows. Resveratrol is the ingredient in red wine thought to improve insulin sensitivity, reduce the risk of heart disease and increase longevity. Although resveratrol supplementation doesn't appear to help these women, it's possible that another ingredient in red wine may provide a health benefit, the researchers from the Washington University School of Medicine in St. Louis pointed out. "Resveratrol supplements have become popular because studies in cell systems and rodents show that resveratrol can improve metabolic function and prevent or reverse certain health problems like diabetes, heart disease and even cancer," senior investigator Dr. Samuel Klein, director of Washington University's Center for Human Nutrition, said in a university news release. "But our data demonstrate ... Read more

Related support groups: Cardiovascular Risk Reduction, Resveratrol

How That Glass of Red Wine Might Help You Live Longer

Posted 1 May 2012 by Drugs.com

TUESDAY, May 1 – Researchers have found new evidence showing that resveratrol, a compound found in red wine, may play a role in preventing cell aging. The study in rodents found that when mice had a particular gene – SIRT1 – knocked out, or turned off, resveratrol had no effect on them. But tests of muscle tissue in mice with a normal SIRT1 gene that were given resveratrol found that the substance boosted mitochondrial function. Mitochondria provide the energy that cells need to function. A decrease in mitochondrial energy production has been linked to a variety of diseases, including diabetes and Alzheimer's disease, as well as to the aging process itself, said senior study author David Sinclair, a professor of genetics at Harvard Medical School in Boston. But don't go reaching for that Chianti yet. Yes, resveratrol is found in the skin of red grapes. But "the amounts we gave to our ... Read more

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Scientists May Be Closer to Developing 'Red Wine' Drug

Posted 2 Feb 2012 by Drugs.com

THURSDAY, Feb. 2 – U.S. researchers believe they've discovered how resveratrol – a chemical found in red wine and other plant products – provides health benefits. The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines. "Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells." Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the ... Read more

Related support groups: Diabetes, Type 2, Heart Disease, Alzheimer's Disease, Resveratrol

Red Wine Antioxidant Could Give Metabolism a Boost

Posted 1 Nov 2011 by Drugs.com

TUESDAY, Nov. 1 – Results of a small study show that obese men who take a small daily dose of the supplement resveratrol – found as a natural compound in red wine – appear to improve their metabolism as much as if they were on a strict low-calorie diet. Animal studies have previously found that resveratrol reduces insulin resistance and protects against the bad effects of a high-fat diet. This is similar to what happens when people restrict the number of calories they take in, which has been shown to delay the onset of age-related diseases, the Dutch researchers say. "Now we have shown for the first time that resveratrol works in humans. It opens the avenue for more research to see if it could be helpful in people with type 2 diabetes," said lead researcher Patrick Schrauwen from Maastricht University in the Netherlands. "This is very positive news," he added. "We need further ... Read more

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