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Propylthiouracil News

Thyroid Treatment Guidelines for Pregnant Women Revised

Posted 14 Aug 2012 by

TUESDAY, Aug. 14 – Thyroid hormone is critical for normal fetal brain development, and hormonal problems among pregnant women must be properly managed, according to the Endocrine Society, which just revised its guidelines on treating thyroid-related medical issues before, during and after pregnancy. Too much or not enough thyroid hormone can harm both women and their unborn babies, the experts said. The treatment guidelines update the 2007 version. "Pregnancy may affect the course of thyroid diseases and, conversely, thyroid diseases may affect the course of pregnancy," said lead study author Dr. Leslie de Groot, a research professor at the University of Rhode Island, in a society news release. "Pregnant women may be under the care of multiple health care professionals, including obstetricians, nurse midwives, family practitioners and endocrinologists, making the development of ... Read more

Related support groups: Hypothyroidism, Underactive Thyroid, Hyperthyroidism, Methimazole, Tapazole, Graves' Disease, Propylthiouracil, Northyx

FDA Drug Safety Communication: New Boxed Warning on severe liver injury with propylthiouracil

Posted 22 Apr 2010 by

Safety Announcement Additional Information for Patients Additional Information for Healthcare Professionals Data Summary Safety Announcement [04-21-2010] The United States Food and Drug Administration (FDA) has added a Boxed Warning to the label for propylthiouracil, a drug used to treat hyperthyroidism (overactive thyroid), to include information about reports of severe liver injury and acute liver failure, some of which have been fatal, in adult and pediatric patients using this medication. The new warning also states that for patients being started on treatment for hyperthyroidism it may be appropriate to reserve use of propylthiouracil for those who cannot tolerate other treatments such as methimazole, radioactive iodine or surgery. In addition, due to the occurrence of birth defects that have been observed with the use of methimazole during the first trimester of pregnancy (see ... Read more

Related support groups: Propylthiouracil

FDA Medwatch Alert: Propylthiouracil

Posted 3 Jun 2009 by

FDA notified healthcare professionals of the risk of serious liver injury, including liver failure and death, with the use of propylthiouracil in adult and pediatric patients. Reports to FDA's Adverse Event Reporting System (AERS) suggest there is an increased risk of hepatotoxicity with proplythiouracil when compared to methimazole. FDA has identified 32 (AERS) cases (22 adult and 10 pediatric) of serious liver injury associated with proplythiouracil use. Although both proplythiouracil and methimazole are indicated for the treatment of hyperthyroidism due to Graves' disease, healthcare professionals should carefully consider which drug to initiate in a patient recently diagnosed with Graves' disease. Physicians should closely monitor patients on proplythiouracil therapy for symptoms and signs of liver injury, especially during the first six months after initiation of therapy. ... Read more

Related support groups: Propylthiouracil

Drug May Be Dangerous for Kids With Graves' Disease

Posted 17 Apr 2009 by

FRIDAY, April 17 – A recommendation to restrict the use of the antithyroid drug (PTU) in children has been endorsed by the Endocrine Society. In a letter to the editor in the April 9 New England Journal of Medicine, two experts wrote that PTU can cause severe liver disease in children and should no longer be used as a first-line treatment for children with Graves' disease, a disorder in which the thyroid gland produces more thyroid hormone than the body needs. Liver damage has not been seen in children treated with the other thionamide derivative, methimazole, noted Dr. Scott A. Rivkees, of Yale University Medical School, and Dr. Donald R. Mattison, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The Endocrine Society said this week that it supports the recommendation. "Despite the relative rarity of Graves' disease in the young, children and ... Read more

Related support groups: Graves' Disease, Propylthiouracil

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Hyperthyroidism, Thyroid Storm, Alcoholic Liver Damage

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