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Are Heartburn Meds During Pregnancy Linked to Asthma in Kids?

Posted 12 days ago by Drugs.com

MONDAY, Jan. 9, 2017 – Women who take certain heartburn medications during pregnancy may have a child at increased risk of developing asthma, new research suggests. For the new study, investigators analyzed eight studies that included more than 1.3 million children. The researchers found that kids born to mothers who were prescribed drugs for acid reflux during pregnancy were at least one-third more likely to have been seen by a doctor for asthma symptoms. Some of the medications come from drug classes that include Tagamet, Zantac, Prilosec, Nexium and Pepcid. "Our study reports an association between the onset of asthma in children and their mothers' use of acid-suppressing medication during pregnancy," said researcher Dr. Aziz Sheikh. He's co-director of the Asthma UK Center for Applied Research, at the University of Edinburgh in Scotland. "It is important to stress that this ... Read more

Related support groups: GERD, Asthma, Omeprazole, Nexium, Prilosec, Asthma - Maintenance, Zantac, Indigestion, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Delivery, Asthma - Acute, Aciphex, Famotidine, Duodenitis/Gastritis

Heartburn Drugs May Raise Risk of Stomach Infections: Study

Posted 16 days ago by Drugs.com

THURSDAY, Jan. 5, 2017 – People who take heartburn drugs such as Prilosec and Nexium may be at increased risk of two potentially serious gut infections, a new study suggests. The study, of nearly 565,000 adults, found those on certain heartburn drugs had higher risks of infection with C. difficile and Campylobacter bacteria. Both bugs cause abdominal pain and diarrhea, but can become more serious – especially C. diff. According to the U.S. Centers for Disease Control and Prevention, almost half a million Americans were sickened by the infection in 2011, and 29,000 of them died within a month. The heartburn drugs in question included both proton pump inhibitors (PPIs) – brands like Prilosec, Prevacid and Nexium – and H2 blockers, such as Zantac, Pepcid and Tagamet, the study authors said. All suppress stomach acid production, and the researchers suspect that may make some people more ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Zantac, Indigestion, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Aciphex, Famotidine, Duodenitis/Gastritis, Heartburn Relief, Rabeprazole, Esomeprazole, Zegerid

Could Common Heartburn Drugs Up Stroke Risk?

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – A popular category of heartburn medications – including Nexium, Prevacid, Prilosec and Protonix – may increase your risk of stroke, a new study suggests. Known as proton pump inhibitors (PPIs), these drugs increased people's overall stroke risk by 21 percent, said study lead author Dr. Thomas Sehested. However, the risk appears to be driven by people who take high doses, added Sehested, research director at the Danish Heart Foundation in Copenhagen. "People treated with a low dose of PPIs did not have a high risk of stroke," he said. "Those treated with the highest doses of PPIs had the highest risk of stroke." The extent of risk also depends on the specific PPI taken. At the highest dose, stroke risk ranged from 30 percent for lansoprazole (Prevacid) to 94 percent for pantoprazole (Protonix), the researchers said. Takeda Pharmaceutical, the maker of ... Read more

Related support groups: GERD, Heart Disease, Ischemic Stroke, Omeprazole, Nexium, Dementia, Prilosec, Zantac, Indigestion, Protonix, Pantoprazole, Alzheimer's Disease, Ranitidine, Lansoprazole, Dexilant, Prevacid, Transient Ischemic Attack, Pepcid, Barrett's Esophagus, Aciphex

Health Tip: Is it Indigestion?

Posted 6 Jun 2016 by Drugs.com

-- If you've eaten too much or indulged in a food that's greasy, fatty or spicy, you may have an uncomfortable feeling known as indigestion. Here are common symptoms, courtesy of the Cleveland Clinic: A burning sensation in the stomach or upper abdomen. An acidic taste in the mouth. Pain in the abdomen. Occasional diarrhea. Bloatedness or gassiness. Vomiting or nausea. Growling stomach. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Zantac, Indigestion, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Tums, Milk of Magnesia, Aciphex, Caltrate, Famotidine, Duodenitis/Gastritis, Heartburn Relief

Clues to How Popular Heartburn Drug Might Harm Arteries

Posted 10 May 2016 by Drugs.com

TUESDAY, May 10, 2016 – A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say. Faster aging of blood vessel cells exposed to the antacid Nexium (esomeprazole) might potentially hinder the tasks these cells perform to prevent heart attack and stroke, the new study suggests. These lab results could explain why other studies have shown increased risk of heart disease in people who use proton pump inhibitors (PPIs) – the class of heartburn medication that includes Nexium, said study senior author Dr. John Cooke. "Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure," said Cooke, chair of cardiovascular sciences at the ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Indigestion, Protonix, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Tums, Milk of Magnesia, Aciphex, Caltrate, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Calcium Carbonate, Zegerid, Prevention of Cardiovascular Disease

1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks

Posted 27 Apr 2016 by Drugs.com

WEDNESDAY, April 27, 2016 – Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report. However, they noted that the use of these medications has started to decline some in recent years. A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said. These drugs include histamine-2 receptor antagonists such as ranitidine (Zantac), and proton pump inhibitors such as esomeprazole (Nexium). Researchers at Nationwide Children's Hospital in Columbus, Ohio, analyzed data from 43 children's hospitals across the United States from 2006 to 2013. They found that nearly 24 percent of roughly 122,000 newborns ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Zantac, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Delivery, Aciphex, Famotidine, Heartburn Relief, Rabeprazole, Esomeprazole, Zegerid, Zantac 150, Vimovo

Doctors Often Overestimate Promise of Newly Approved Drugs

Posted 12 Apr 2016 by Drugs.com

TUESDAY, April 12, 2016 – Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits, researchers warn. The U.S. Congress in 2012 gave FDA the power to designate a drug as a "breakthrough therapy" if preliminary clinical evidence suggests an advantage over existing medications. But a survey of nearly 700 doctors revealed that many tended to misinterpret "breakthrough." Doctors often believed the drugs were supported by stronger evidence than the law requires to achieve that designation, said lead author Dr. Aaron Kesselheim. He is a faculty member at Brigham and Women's Hospital in Boston. "When people hear 'breakthrough,' it gives them an inappropriately elevated sense of what the drug might do," Kesselheim said. "It may give physicians false reassurance about the outcomes they might ... Read more

Related support groups: Nexium, Prilosec, Diagnosis and Investigation

Widely Used Heartburn Drugs Linked to Dementia Risk in Study

Posted 15 Feb 2016 by Drugs.com

MONDAY, Feb. 15, 2016 – A popular class of heartburn medications might raise a senior's risk of dementia, a new study suggests. Called proton pump inhibitors (PPIs), this group of drugs includes Prilosec, Nexium and Prevacid. They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs. The study only found an association, however, and not a cause-and-effect link. "To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed," said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn. In the meantime, "Clinicians should follow guidelines for PPI ... Read more

Related support groups: GERD, Gas, Omeprazole, Nexium, Dementia, Prilosec, Indigestion, Protonix, Pantoprazole, Alzheimer's Disease, Stomach Ulcer, Lansoprazole, Dexilant, Prevacid, Gastric Ulcer, Aciphex, Peptic Ulcer, Duodenitis/Gastritis, Prevpac, Rabeprazole

Could a Lung Cancer Drug Work Better With Coke?

Posted 13 Feb 2016 by Drugs.com

FRIDAY, Feb. 12, 2016 – Patients with the leading form of lung cancer may be able to look to Coca-Cola Classic to solve a common medicinal challenge, new research suggests. As the Dutch scientists explain it, the effectiveness of the powerful lung cancer drug Tarceva (erlotinib) depends on the pH level of the stomach. But many people on Tarceva must also take a proton pump inhibitor heartburn medication – such as Nexium or Prilosec – which raises stomach pH to more alkaline levels. That higher pH can lower the absorption rate for Tarceva, cutting its effectiveness in fighting non-small-cell lung cancer, research suggests. One prior study involving healthy volunteers found the use of Prilosec lowered blood concentrations of Tarceva by 61 percent. What to do? In the new study, researchers led by Dr. Roelof van Leeuwen, of Erasmus MC Cancer Institute in Rotterdam, the Netherlands, ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Non-Small Cell Lung Cancer, Tarceva, Tasigna, Sprycel, Esomeprazole, Prilosec OTC, Iressa, Dasatinib, Nilotinib, Erlotinib, Gefitinib, Protonix IV, Nexium 24HR, Nexium IV, Omesec

Heartburn Meds Linked to Chronic Kidney Disease

Posted 11 Jan 2016 by Drugs.com

MONDAY, Jan. 11, 2016 – A type of heartburn medication called proton pump inhibitors may be linked to long-term kidney damage, a new study suggests. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine. The study doesn't establish a direct cause-and-effect relationship between the drugs and chronic kidney disease. However, Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real." Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Renal Failure, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Chronic Kidney Disease, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease

Posted 27 Oct 2015 by Drugs.com

TUESDAY, Oct. 27, 2015 – A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. While the current studies have shown an association between these drugs and the development of chronic kidney disease, they did not prove a cause-and-effect relationship. Still, the lead author of one of the studies believes, "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease," said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. "Patients should only use PPIs for [U.S. Food and Drug Administration]-approved indications, and ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, GERD, Hypertension, Omeprazole, Nexium, Prilosec, Indigestion, Protonix, Renal Failure, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Chronic Kidney Disease, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Zegerid

Popular Heartburn Meds Linked to Higher Risk of Heart Attack

Posted 10 Jun 2015 by Drugs.com

WEDNESDAY, June 10, 2015 – People who use certain heartburn drugs for a long period of time may have a slightly heightened risk of suffering a heart attack, a new study suggests. Using medical records from nearly 300,000 U.S. adults with acid reflux disease (commonly called heartburn), researchers found that the risk of heart attack was slightly elevated among those using proton pump inhibitors. Proton pump inhibitors are a group of acid-suppressing drugs that include brand-names such as Prevacid, Prilosec and Nexium. In 2009, they were the third most commonly used type of drug in the United States, the researchers said. The study, funded by the U.S. National Institutes of Health, does not prove the drugs cause heart attack. And experts were divided over what to make of the connection. Another class of heartburn drug – so-called H2-blockers – was not linked to any increase in heart ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Indigestion, Protonix, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC

Teva Receives FDA Approval for First Generic Nexium Delayed-Release Capsules in the U.S.

Posted 26 Jan 2015 by Drugs.com

JERUSALEM--(BUSINESS WIRE)--Jan. 26, 2015-- Teva Pharmaceutical Industries Ltd. (NYSE:TEVA) announces the Food and Drug Administration (FDA) approval of the first generic equivalent to Nexium (esomeprazole magnesium) Delayed-Release Capsules in the United States. Teva is preparing to launch the product in the near future. Nexium Delayed-Release Capsules, marketed by AstraZeneca, had annual sales of approximately $6 billion in the United States, according to IMS data as of November 2014. About Teva Teva Pharmaceutical Industries Ltd. is a leading global pharmaceutical company, committed to increasing access to high-quality healthcare by developing, producing and marketing affordable generic drugs as well as innovative and specialty pharmaceuticals and active pharmaceutical ingredients. Headquartered in Israel, Teva is the world's leading generic drug maker, with a global product ... Read more

Related support groups: GERD, Nexium, Esomeprazole, Nexium IV

Antacids May Improve Head and Neck Cancer Survival

Posted 2 Dec 2014 by Drugs.com

TUESDAY, Dec. 2, 2014 – Using antacids to control acid reflux may improve head and neck cancer patients' chances of survival, a new study suggests. The researchers examined the effects that two types of antacids – proton pump inhibitors and histamine 2 blockers – had on head and neck cancer patients. More than two-thirds of the nearly 600 patients in the study took one or both types of the antacids after their cancer diagnosis. Acid reflux – commonly known as heartburn – is a common side effect of chemotherapy or radiation treatment, according to the researchers. Proton pump inhibitors include drugs such as Prilosec, Nexium and Prevacid, while histamine 2 blockers include drugs such as Tagamet, Zantac and Pepcid. Compared to patients who didn't take antacids, those who took proton pump inhibitors had a 45 percent lower risk of death, according to the researchers. They also found ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Zantac, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Aciphex, Famotidine, Heartburn Relief, Rabeprazole, Esomeprazole, Zegerid, Zantac 150, Pepcid AC, Pepcid Complete

Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs?

Posted 25 Nov 2014 by Drugs.com

TUESDAY, Nov. 25, 2014 – Heartburn drugs such as Prilosec and Nexium may disrupt the makeup of bacteria in the digestive system, potentially boosting the risk of infections and other problems, a small new study suggests. The research doesn't confirm that these changes make it more likely users will become ill, and study authors aren't recommending that anyone stop taking the so-called proton pump inhibitors. However, these antacids "should be used at the lowest dose that provides adequate relief of symptoms, and attempts to discontinue their use should be considered periodically," said study co-author Dr. John DiBaise, professor of medicine at the Mayo Clinic in Scottsdale, Ariz. According to Harvard Medical School, billions of dollars are spent annually on antacid drugs in an attempt to combat heartburn, ulcers and gastroesophageal reflux disease, also known as GERD. Old standbys such ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

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